{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Chen X"],"pubmed_abstract":["<h4>Background</h4>As the most important pathophysiological process of obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) could cause cognitive impairment. Our previous study showed that Shengmai Dihuang Decoction (SDD) improved CIH-induced cognitive impairment. However, the precise underlying mechanism remains unclear.<h4>Objective</h4>This study aims to investigate the role of the insulin-like growth factor 1 (IGF1)/insulin-like growth factor 1 receptor (IGFR) signaling pathway in improving CIH-induced neuronal injury by SDD treatment.<h4>Methods</h4>In this study, HT22 cells were cultured under CIH conditions (O<sub>2</sub>: 21-0.1 %, 6 cycles/h). Cell ability was assessed by CCK-8 assay, and Mitochondrial damage was detected by transmission electron microscopy (TEM), mit"],"journal":["Journal of traditional and complementary medicine"],"pagination":["31-45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12902252"],"repository":["biostudies-literature"],"pubmed_title":["Role of IGF1/IGFR signaling pathway in neuroprotective effect of Shengmai Dihuang Decoction on CIH-induced cognitive impairment."],"pmcid":["PMC12902252"],"pubmed_authors":["Sun M","Fan X","Qi K","Li D","Si J","Ji E","Chen X","Yang S"],"additional_accession":[]},"is_claimable":false,"name":"Role of IGF1/IGFR signaling pathway in neuroprotective effect of Shengmai Dihuang Decoction on CIH-induced cognitive impairment.","description":"<h4>Background</h4>As the most important pathophysiological process of obstructive sleep apnea (OSA), chronic intermittent hypoxia (CIH) could cause cognitive impairment. Our previous study showed that Shengmai Dihuang Decoction (SDD) improved CIH-induced cognitive impairment. However, the precise underlying mechanism remains unclear.<h4>Objective</h4>This study aims to investigate the role of the insulin-like growth factor 1 (IGF1)/insulin-like growth factor 1 receptor (IGFR) signaling pathway in improving CIH-induced neuronal injury by SDD treatment.<h4>Methods</h4>In this study, HT22 cells were cultured under CIH conditions (O<sub>2</sub>: 21-0.1 %, 6 cycles/h). Cell ability was assessed by CCK-8 assay, and Mitochondrial damage was detected by transmission electron microscopy (TEM), mit","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T21:59:56.31Z","creation":"2026-07-09T10:20:11.916Z"},"accession":"S-EPMC12902252","cross_references":{"pubmed":["41696739"],"doi":["10.1016/j.jtcme.2024.11.014"]}}