biostudies-literatureUnknown123Huang PHope for Depression Research FoundationJacobs FoundationNational Medical Research CouncilNational Research FoundationJPB Foundation<h4>Background</h4>Infant screen time is linked to many negative outcomes, including anxiety, but the underlying neural correlates and pathways remains understudied. We aimed to assess the directional association between infant screen time, development of brain network topology, decision-making behaviour and anxiety symptoms in adolescence.<h4>Methods</h4>Using data from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study, we examined the effects of total daily screen time for infants on developmental outcomes using structural equation modelling. Specifically, we looked at the developmental slopes of network integration for the seven major brain cortical networks between ages 4.5, 6.0, and 7.5, decision-making behaviour assessed using the Cambridge Gambling Task (CGT)EBioMedicine106093https://www.ebi.ac.uk/biostudies/studies/S-EPMC12902254biostudies-literatureNeurobehavioural links from infant screen time to anxiety.PMC12902254Manahan AMAMeaney MJZhou KXZhou HJFortier MVChan SYChuah JShorey SChong YSLaw ECNTan APHuang PfalseNeurobehavioural links from infant screen time to anxiety.<h4>Background</h4>Infant screen time is linked to many negative outcomes, including anxiety, but the underlying neural correlates and pathways remains understudied. We aimed to assess the directional association between infant screen time, development of brain network topology, decision-making behaviour and anxiety symptoms in adolescence.<h4>Methods</h4>Using data from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study, we examined the effects of total daily screen time for infants on developmental outcomes using structural equation modelling. Specifically, we looked at the developmental slopes of network integration for the seven major brain cortical networks between ages 4.5, 6.0, and 7.5, decision-making behaviour assessed using the Cambridge Gambling Task (CGT)2026-01-01T00:00:00Z2026 Jan2026-07-15T15:35:34.763Z2026-07-06T03:10:41.747ZS-EPMC129022544146928710.1016/j.ebiom.2025.106093