biostudies-literatureUnknown11(5)Li LThe development of liquid embolic agents has significantly advanced the field of transcatheter arterial embolization (TAE). Conventional solid embolic agents, such as gelatin sponges or poly-(vinyl alcohol) (PVA), are limited by their lack of intrinsic radiopacity and reliance on lipiodol, necessitating a cumbersome two-step embolization process. Consequently, a critical need exists for embolic materials that combine intrinsic imaging functionality with enhanced biocompatibility to advance clinical outcomes. We have developed a novel liquid embolic material based on poly-(<i>N</i>-isopropylacrylamide)-<i>co</i>-acrylic acid nanogels (PNAs). Mixing PNAs with lipiodol using a medical three-way stopcock yields a thermosensitive lipiodol-based gel emulsion (TLGE). This material exhibits excellACS omega7451-7463https://www.ebi.ac.uk/biostudies/studies/S-EPMC12902837biostudies-literatureA Radiopaque and Thermoresponsive Nanogel-Based Pickering Emulsion for Permanent Arterial Embolization.PMC12902837Chen NXing JCao YLiu AZhang LCheng GLi LYu HfalseA Radiopaque and Thermoresponsive Nanogel-Based Pickering Emulsion for Permanent Arterial Embolization.The development of liquid embolic agents has significantly advanced the field of transcatheter arterial embolization (TAE). Conventional solid embolic agents, such as gelatin sponges or poly-(vinyl alcohol) (PVA), are limited by their lack of intrinsic radiopacity and reliance on lipiodol, necessitating a cumbersome two-step embolization process. Consequently, a critical need exists for embolic materials that combine intrinsic imaging functionality with enhanced biocompatibility to advance clinical outcomes. We have developed a novel liquid embolic material based on poly-(<i>N</i>-isopropylacrylamide)-<i>co</i>-acrylic acid nanogels (PNAs). Mixing PNAs with lipiodol using a medical three-way stopcock yields a thermosensitive lipiodol-based gel emulsion (TLGE). This material exhibits excell2026-01-01T00:00:00Z2026 Feb2026-07-15T15:36:12.632Z2026-07-06T03:11:01.206ZS-EPMC129028374169623510.1021/acsomega.5c08513