biostudies-literatureUnknown11(5)Ikeda KThis study examines the structural organization of low transition temperature mixtures (LTTMs) based on coniferyl alcohol, a primary monolignol, at the macroscopic and microscopic levels. The work presents the first investigation into the use of lignin-derived monomers as constituents of LTTMs. The LTTMs prepared with 2:1 and 3:1 molar ratios of coniferyl alcohol to choline chloride exhibited glass transition temperatures (T g) of -24.6 and -16.8 °C, respectively, and with no observable melting points (T m). The respective water contents were 0.4790 and 0.7564 wt %, similar to that reported for other natural deep eutectic solvents. Time-domain nuclear magnetic resonance analysis revealed that these LTTMs are heterogeneous and exhibited two regions betweeACS omega7501-7507https://www.ebi.ac.uk/biostudies/studies/S-EPMC12902860biostudies-literatureStructural Properties of Coniferyl Alcohol-Based Low Transition Temperature Mixtures.PMC12902860Ikeda KKarasawa TTominaga YMiyazawa THorikawa YKimura KKato TMatsushita YfalseStructural Properties of Coniferyl Alcohol-Based Low Transition Temperature Mixtures.This study examines the structural organization of low transition temperature mixtures (LTTMs) based on coniferyl alcohol, a primary monolignol, at the macroscopic and microscopic levels. The work presents the first investigation into the use of lignin-derived monomers as constituents of LTTMs. The LTTMs prepared with 2:1 and 3:1 molar ratios of coniferyl alcohol to choline chloride exhibited glass transition temperatures (T g) of -24.6 and -16.8 °C, respectively, and with no observable melting points (T m). The respective water contents were 0.4790 and 0.7564 wt %, similar to that reported for other natural deep eutectic solvents. Time-domain nuclear magnetic resonance analysis revealed that these LTTMs are heterogeneous and exhibited two regions betwee2026-01-01T00:00:00Z2026 Feb2026-07-15T22:02:50.662Z2026-07-09T10:19:26.869ZS-EPMC129028604169629410.1021/acsomega.5c08613