{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["65"],"submitter":["Labroy M"],"pubmed_abstract":["<h4>Background</h4>Photodynamic diagnosis (PDD) is widely used in bladder cancer management, enabling fluorescence-guided detection of lesions through intravesical administration of photosensitizers such as hexaminolevulinate (Cysview®/Hexvix®). Building on this clinical framework, we explored photodynamic therapy (PDT) using pheophorbide a (pheo), a chlorophyll-based photosensitizer, encapsulated in self-assembled poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO<sub>5000</sub>-PCL<sub>4000</sub>) micelles.<h4>Results</h4>In vitro assays were performed on human bladder cancer cell lines, namely the grade 3 invasive T24 and the grade 1 SW780, in both 2D monolayers and 3D spheroid cultures. In 2D, encapsulated pheo showed higher phototoxicity (IC₅₀: 129 nM T24, 156 nM SW780), while free "],"journal":["Translational oncology"],"pagination":["102687"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12903199"],"repository":["biostudies-literature"],"pubmed_title":["Improving photodynamic therapy efficacy in bladder cancer using polymer micelle-encapsulated pheophorbide a."],"pmcid":["PMC12903199"],"pubmed_authors":["Fourquaux I","Gibot L","Bolduc S","Bordeleau F","Chabaud S","Labroy M","Durand M"],"additional_accession":[]},"is_claimable":false,"name":"Improving photodynamic therapy efficacy in bladder cancer using polymer micelle-encapsulated pheophorbide a.","description":"<h4>Background</h4>Photodynamic diagnosis (PDD) is widely used in bladder cancer management, enabling fluorescence-guided detection of lesions through intravesical administration of photosensitizers such as hexaminolevulinate (Cysview®/Hexvix®). Building on this clinical framework, we explored photodynamic therapy (PDT) using pheophorbide a (pheo), a chlorophyll-based photosensitizer, encapsulated in self-assembled poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO<sub>5000</sub>-PCL<sub>4000</sub>) micelles.<h4>Results</h4>In vitro assays were performed on human bladder cancer cell lines, namely the grade 3 invasive T24 and the grade 1 SW780, in both 2D monolayers and 3D spheroid cultures. In 2D, encapsulated pheo showed higher phototoxicity (IC₅₀: 129 nM T24, 156 nM SW780), while free ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-06T03:14:33.156Z","creation":"2026-07-06T03:10:47.087Z"},"accession":"S-EPMC12903199","cross_references":{"pubmed":["41650805"],"doi":["10.1016/j.tranon.2026.102687"]}}