{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McKenzie C"],"funding":["NIA NIH HHS","U.S. Department of Defense","National Institutes of Health","CIHR"],"pagination":["119-127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12903205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88"],"pubmed_abstract":["Cognitive reserve has been described as offering protection against Alzheimer's disease (AD) and other neurodegenerative conditions, but also against age-associated brain changes. Using data from the Alzheimer's Disease Neuroimaging Initiative, we defined cognitive reserve using the residual reserve index: episodic memory performance residualized for 3T MRI-derived brain volumes and demographics. We examined whether cognitive reserve predicted executive function (EF) decline equally across 2 groups of older adults-AD biomarker-positive (n = 468) and -negative (n = 402)-defined by the tau-to-amyloid ratio in cerebrospinal fluid. A significant interaction between the residual reserve index and biomarker group revealed that the effect of cognitive reserve on EF decline was dependent on pathol"],"journal":["Neurobiology of aging"],"pubmed_title":["Cognitive reserve predicts future executive function decline in older adults with Alzheimer's disease pathology but not age-associated pathology."],"pmcid":["PMC12903205"],"funding_grant_id":["U01 AG024904"],"pubmed_authors":["Bourgeat P","Alzheimer's Disease Neuroimaging Initiative","McKenzie C","Weinborn M","Bucks RS","Salvado O","Gavett BE"],"additional_accession":[]},"is_claimable":false,"name":"Cognitive reserve predicts future executive function decline in older adults with Alzheimer's disease pathology but not age-associated pathology.","description":"Cognitive reserve has been described as offering protection against Alzheimer's disease (AD) and other neurodegenerative conditions, but also against age-associated brain changes. Using data from the Alzheimer's Disease Neuroimaging Initiative, we defined cognitive reserve using the residual reserve index: episodic memory performance residualized for 3T MRI-derived brain volumes and demographics. We examined whether cognitive reserve predicted executive function (EF) decline equally across 2 groups of older adults-AD biomarker-positive (n = 468) and -negative (n = 402)-defined by the tau-to-amyloid ratio in cerebrospinal fluid. A significant interaction between the residual reserve index and biomarker group revealed that the effect of cognitive reserve on EF decline was dependent on pathol","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2026-07-15T15:34:33.8Z","creation":"2026-07-06T03:11:23.116Z"},"accession":"S-EPMC12903205","cross_references":{"pubmed":["31980279"],"doi":["10.1016/j.neurobiolaging.2019.12.022"]}}