{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(7)"],"submitter":["Aman S"],"pubmed_abstract":["Allomelanin is a nitrogen-free class of melanin commonly found in plants and fungi. Although synthetic analogs have been developed from 1,8-dihydroxynaphthalene (1,8-DHN), detailed physicochemical comparisons with natural allomelanins remain limited. Herein, we extracted allomelanin from black knot fungus, chaga mushroom, and black oat using an acid-base extraction protocol, comparing them against a library of synthetic analogs derived from a range of putative, natural precursors. Spectroscopic analyses indicate that simple homopolymerization of 1,8-DHN does not adequately represent natural allomelanin structures. Instead, heterogeneous copolymerization of 1,8-DHN with catechol or tannic acid yields materials with physicochemical properties more consistent with natural extracts. This is al"],"journal":["Science advances"],"pagination":["eady4848"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12904162"],"repository":["biostudies-literature"],"pubmed_title":["Exploring allomelanin: A comparative analysis via natural product extraction and synthesis."],"pmcid":["PMC12904162"],"pubmed_authors":["Siwicka ZE","Wasielewski MR","Kalaj BN","Karanjkar P","Latawiec EI","Gianneschi NC","Farha OK","Su S","La Clair JJ","Aman S","Dhinojwala A","Burkart MD","Irie LM"],"additional_accession":[]},"is_claimable":false,"name":"Exploring allomelanin: A comparative analysis via natural product extraction and synthesis.","description":"Allomelanin is a nitrogen-free class of melanin commonly found in plants and fungi. Although synthetic analogs have been developed from 1,8-dihydroxynaphthalene (1,8-DHN), detailed physicochemical comparisons with natural allomelanins remain limited. Herein, we extracted allomelanin from black knot fungus, chaga mushroom, and black oat using an acid-base extraction protocol, comparing them against a library of synthetic analogs derived from a range of putative, natural precursors. Spectroscopic analyses indicate that simple homopolymerization of 1,8-DHN does not adequately represent natural allomelanin structures. Instead, heterogeneous copolymerization of 1,8-DHN with catechol or tannic acid yields materials with physicochemical properties more consistent with natural extracts. This is al","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T18:04:16.186Z","creation":"2026-07-08T03:08:31.976Z"},"accession":"S-EPMC12904162","cross_references":{"pubmed":["41686886"],"doi":["10.1126/sciadv.ady4848"]}}