biostudies-literatureUnknown32(1)Lu HPfizer Inc<h4>Introduction</h4>The expansion of haemophilia treatment to include non-factor prophylaxis provides new options with various benefits, risks, administration modes, and device types, necessitating trade-offs in decision-making.<h4>Aim</h4>This study evaluated prophylactic treatment preferences of people with haemophilia and their caregivers, assessing their willingness to make trade-offs among treatment attributes.<h4>Methods</h4>A web-based survey containing a discrete-choice experiment (DCE) was completed by adults (≥ 18 years old) and caregivers of children (aged 8-17 years) with haemophilia in the United States and United Kingdom. Participants were asked to complete 10 choice tasks, choosing their preferred prophylaxis from two hypothetical profiles defined by seven attributes. The pHaemophilia : the official journal of the World Federation of Hemophilia116-130https://www.ebi.ac.uk/biostudies/studies/S-EPMC12904171biostudies-literaturePatient and Caregiver Preferences for Long-Term Prophylactic Treatment of Bleeds in Haemophilia: A Discrete-Choice Experiment.PMC12904171Whitty JACoulter JSohn AWilcox LJChristopher SAGutierrez-Vargas AADunn NLu HColavecchia CHauber BCappelleri JCGould TChowdary PfalsePatient and Caregiver Preferences for Long-Term Prophylactic Treatment of Bleeds in Haemophilia: A Discrete-Choice Experiment.<h4>Introduction</h4>The expansion of haemophilia treatment to include non-factor prophylaxis provides new options with various benefits, risks, administration modes, and device types, necessitating trade-offs in decision-making.<h4>Aim</h4>This study evaluated prophylactic treatment preferences of people with haemophilia and their caregivers, assessing their willingness to make trade-offs among treatment attributes.<h4>Methods</h4>A web-based survey containing a discrete-choice experiment (DCE) was completed by adults (≥ 18 years old) and caregivers of children (aged 8-17 years) with haemophilia in the United States and United Kingdom. Participants were asked to complete 10 choice tasks, choosing their preferred prophylaxis from two hypothetical profiles defined by seven attributes. The p2026-01-01T00:00:00Z2026 Jan-Feb2026-07-09T13:20:55.546Z2026-07-09T13:09:35.726ZS-EPMC129041714135867310.1111/hae.70172