{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Simbrunner B"],"funding":["Austrian Science Fund FWF","Clinical Research Groups Programme of the Ludwig Boltzmann Gesellschaft","Österreichische Gesellschaft für Gastroenterologie und Hepatologie","Medical Scientific Fund of the Mayor of the City of Vienna"],"pagination":["648-661"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12904196"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(5)"],"pubmed_abstract":["<h4>Background</h4>Extracellular matrix (ECM) remodelling in advanced chronic liver disease (ACLD) is characterised by hepatic fibrosis and (sinusoidal) basement membrane development contributing to portal hypertension (PH) and clinical complications.<h4>Methods</h4>Patients with stable ACLD (n = 232) undergoing hepatic venous pressure gradient (HVPG) measurement were included. Blood biomarkers reflecting fibrosis formation (PRO-C3, PRO-C6, PRO-C4 and PRO-C18L) and degradation (C3M, C4M and C6Ma3), as well as the Enhanced Liver Fibrosis (ELF) score were measured. Associations with disease severity and liver-related events (LRE: decompensation, acute-on-chronic liver failure, or liver-related death) were analysed.<h4>Results</h4>The cohort included 131 (57%) patients with decompensated ACLD"],"journal":["Alimentary pharmacology & therapeutics"],"pubmed_title":["Biomarkers of Extracellular Matrix Remodelling Are Linked to Severity and Outcome of Advanced Chronic Liver Disease."],"pmcid":["PMC12904196"],"funding_grant_id":["J-4934","Wissenschaftsfoerderung_2022","LBG_KFG_22_32","21047","J‐4934"],"pubmed_authors":["Semmler G","Scheiner B","Balcar L","Marculescu R","Trauner M","Almeida Calvao J","Mandorfer M","Leeming DJ","Simbrunner B","Kramer G","Jachs M","Karsdal M","Villesen IF","Reiberger T","Maurer J","Zinober K","Hartl L","Hofer BS"],"additional_accession":[]},"is_claimable":false,"name":"Biomarkers of Extracellular Matrix Remodelling Are Linked to Severity and Outcome of Advanced Chronic Liver Disease.","description":"<h4>Background</h4>Extracellular matrix (ECM) remodelling in advanced chronic liver disease (ACLD) is characterised by hepatic fibrosis and (sinusoidal) basement membrane development contributing to portal hypertension (PH) and clinical complications.<h4>Methods</h4>Patients with stable ACLD (n = 232) undergoing hepatic venous pressure gradient (HVPG) measurement were included. Blood biomarkers reflecting fibrosis formation (PRO-C3, PRO-C6, PRO-C4 and PRO-C18L) and degradation (C3M, C4M and C6Ma3), as well as the Enhanced Liver Fibrosis (ELF) score were measured. Associations with disease severity and liver-related events (LRE: decompensation, acute-on-chronic liver failure, or liver-related death) were analysed.<h4>Results</h4>The cohort included 131 (57%) patients with decompensated ACLD","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-15T18:01:57.218Z","creation":"2026-07-08T03:08:27.231Z"},"accession":"S-EPMC12904196","cross_references":{"pubmed":["41077886"],"doi":["10.1111/apt.70407"]}}