{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rotbain Curovic V"],"funding":["NCATS NIH HHS","NIA NIH HHS","NIDDK NIH HHS"],"pagination":["110119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12904338"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["193"],"pubmed_abstract":["<h4>Background</h4>Baseline risk variables and visit-to-visit variability (VV) of systolic blood pressure (SBP), HbA<sub>1c</sub>, serum creatinine, and uric acid (UA) are potential risk markers of kidney function decline in type 1 diabetes.<h4>Methods</h4>Post-hoc analysis of a double-blind randomized placebo-controlled clinical trial investigating allopurinol's effect on iohexol-derived glomerular filtration rate (iGFR) in type 1 diabetes with elevated UA. Primary outcome was iGFR change over three years. Linear regression with backwards selection of baseline clinical variables was performed to identify an optimized model forecasting iGFR change. Furthermore, VVs of SBP, HbA<sub>1c</sub>, serum creatinine, and UA were calculated using measurements from the run-in period; thereafter asses"],"journal":["Diabetes research and clinical practice"],"pubmed_title":["Baseline risk markers and visit-to-visit variability in relation to kidney outcomes - A post-hoc analysis of the PERL study."],"pmcid":["PMC12904338"],"funding_grant_id":["UL1 TR002494","UC4 DK101108","P30 DK020572","UL1 TR002378","P30 DK036836","R03 DK094484","UL1 TR002556","P30 DK111024","UL1 TR002319","R34 DK097808","P30 AG024824"],"pubmed_authors":["Hansen TW","Polsky S","PERL Study Group","Rossing P","Sigal RJ","Lingvay I","Pop-Busui R","Tuttle KR","Umpierrez GE","Rotbain Curovic V","Wallia A","Luiza Caramori M","Hirsch IB","De Boer IH","Rosas SE","Cherney DZ","Mcgill JB","Roy N","Emanuele MA"],"additional_accession":[]},"is_claimable":false,"name":"Baseline risk markers and visit-to-visit variability in relation to kidney outcomes - A post-hoc analysis of the PERL study.","description":"<h4>Background</h4>Baseline risk variables and visit-to-visit variability (VV) of systolic blood pressure (SBP), HbA<sub>1c</sub>, serum creatinine, and uric acid (UA) are potential risk markers of kidney function decline in type 1 diabetes.<h4>Methods</h4>Post-hoc analysis of a double-blind randomized placebo-controlled clinical trial investigating allopurinol's effect on iohexol-derived glomerular filtration rate (iGFR) in type 1 diabetes with elevated UA. Primary outcome was iGFR change over three years. Linear regression with backwards selection of baseline clinical variables was performed to identify an optimized model forecasting iGFR change. Furthermore, VVs of SBP, HbA<sub>1c</sub>, serum creatinine, and UA were calculated using measurements from the run-in period; thereafter asses","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-07-15T15:39:17.956Z","creation":"2026-07-06T03:11:26.725Z"},"accession":"S-EPMC12904338","cross_references":{"pubmed":["36265753"],"doi":["10.1016/j.diabres.2022.110119"]}}