{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(2)"],"submitter":["Dadarwal D"],"pubmed_abstract":["This study aimed to evaluate the effects of a single postpartum administration of pegbovigrastim, a recombinant bovine granulocyte colony-stimulating factor (rG-CSF), on peripheral leukocyte profiles, granulocyte function, and uterine cytology in healthy Holstein dairy cows. We hypothesized that rG-CSF would enhance leukocyte counts and granulocyte function without adversely affecting uterine immune cell composition. Twenty-three cows between 19-23 days in milk were randomly assigned to receive either rG-CSF (n = 12) or saline (n = 11). Blood samples were collected on the day of injection and on Days 3, 6, 10, and 21 post-treatment to assess total and differential leukocyte counts. Granulocyte phagocytosis of fluorescein isothiocyanate (FITC)-labeled Staphylococcus aureus and oxidative bur"],"journal":["PloS one"],"pagination":["e0342743"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12904405"],"repository":["biostudies-literature"],"pubmed_title":["Parenterally administered pegbovigrastim alters leukocyte counts, granulocyte functions, and uterine cell population in healthy postpartum dairy cows."],"pmcid":["PMC12904405"],"pubmed_authors":["Ahmed KA","Palmer C","Lainetti P","Dadarwal D","Dickinson R","Crooks K"],"additional_accession":[]},"is_claimable":false,"name":"Parenterally administered pegbovigrastim alters leukocyte counts, granulocyte functions, and uterine cell population in healthy postpartum dairy cows.","description":"This study aimed to evaluate the effects of a single postpartum administration of pegbovigrastim, a recombinant bovine granulocyte colony-stimulating factor (rG-CSF), on peripheral leukocyte profiles, granulocyte function, and uterine cytology in healthy Holstein dairy cows. We hypothesized that rG-CSF would enhance leukocyte counts and granulocyte function without adversely affecting uterine immune cell composition. Twenty-three cows between 19-23 days in milk were randomly assigned to receive either rG-CSF (n = 12) or saline (n = 11). Blood samples were collected on the day of injection and on Days 3, 6, 10, and 21 post-treatment to assess total and differential leukocyte counts. Granulocyte phagocytosis of fluorescein isothiocyanate (FITC)-labeled Staphylococcus aureus and oxidative bur","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-07T03:16:30.019Z","creation":"2026-07-07T03:09:56.946Z"},"accession":"S-EPMC12904405","cross_references":{"pubmed":["41686821"],"doi":["10.1371/journal.pone.0342743"]}}