biostudies-literatureWu KFDalin Tzu Chi Hospital20451253261419626https://www.ebi.ac.uk/biostudies/studies/S-EPMC12905104biostudies-literatureUnknown16<h4>Background</h4>Inadequate adherence to antipsychotic medication remains a major driver of relapse, hospitalization, and chronic disease progression in schizophrenia. Long-acting injectable (LAI) antipsychotics may reduce healthcare costs and the risk of relapse. However, evidence regarding the switch from paliperidone palmitate once every month (PP1M) to paliperidone palmitate once every 3 months (PP3M) remains limited.<h4>Objectives</h4>To examine the utilization of LAI antipsychotics and investigate the effect of transitioning from PP1M to PP3M on adherence and healthcare utilization.<h4>Design</h4>This retrospective, 12-month mirror-image study used nationwide, population-based data from Taiwan to examine changes in healthcare resource utilization and costs after the transition fromTherapeutic advances in psychopharmacologyHealthcare resource savings from administering paliperidone palmitate once every 3 months instead of once every month for schizophrenia: a 12-month mirror-image analysis of real-world population-based data.PMC12905104DTCRD113-E-04DTCRD110(2)-E-07Yang YHWu KFTsai JHChuang HYHung CSfalseHealthcare resource savings from administering paliperidone palmitate once every 3 months instead of once every month for schizophrenia: a 12-month mirror-image analysis of real-world population-based data.<h4>Background</h4>Inadequate adherence to antipsychotic medication remains a major driver of relapse, hospitalization, and chronic disease progression in schizophrenia. Long-acting injectable (LAI) antipsychotics may reduce healthcare costs and the risk of relapse. However, evidence regarding the switch from paliperidone palmitate once every month (PP1M) to paliperidone palmitate once every 3 months (PP3M) remains limited.<h4>Objectives</h4>To examine the utilization of LAI antipsychotics and investigate the effect of transitioning from PP1M to PP3M on adherence and healthcare utilization.<h4>Design</h4>This retrospective, 12-month mirror-image study used nationwide, population-based data from Taiwan to examine changes in healthcare resource utilization and costs after the transition from2026-01-01T00:00:00Z20262026-07-15T21:24:41.766Z2026-07-09T10:14:08.719ZS-EPMC129051044169379610.1177/20451253261419626