{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cramer P"],"funding":["Deutsche Forschungsgemeinschaft (DFG)","University of Rijeka","croatian science foundation"],"pagination":["795-823"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12905349"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Virus infections elicit long-term IgG antibody and memory responses. Human cytomegalovirus (HCMV) is widespread in humans and disseminates despite the presence of virus-specific antibodies. Here, we report that the HCMV Fcγ-binding glycoprotein 34 modulates humoral immunity by binding to IgG⁺ memory B cells. gp34-B cell receptor (BCR) interaction initiates activation of the PDK1/AKT/mTOR/S6 pathway and BCR internalization in a SYK-independent manner. Prolonged stimulation also induces B-cell activation via upregulation of CD69 and CD86. In a T-cell-dependent response, however, interaction with gp34 blocks B-cell proliferation, differentiation into plasmablasts, and soluble IgG production, while stimulating TNF-α secretion. Through gp34 stimulation on IgG⁺ B cells, neighboring IgM⁺ and IgA⁺"],"journal":["EMBO molecular medicine"],"pubmed_title":["A viral glycoprotein targets IgG<sup>+</sup> memory B cells to mediate humoral immune evasion."],"pmcid":["PMC12905349"],"funding_grant_id":["SFP1160","HE2526/9-2","468499998","KK.01.1.1.01.0006","IP-2020-02-6617","uniri-biomed-18-233","JO1634/1-1"],"pubmed_authors":["Kolb P","Falcone V","Rizzi M","Lenac Rovis T","Janowska I","Jonjic S","Neys SFH","Fiedler M","Kohl AK","Staniek J","Plachter B","Cramer P","Huber M","Read C","Hoffmann K","Hadlova P","Reinhard H","von Einem J","Lorenzetti R","Hengel H"],"additional_accession":[]},"is_claimable":false,"name":"A viral glycoprotein targets IgG<sup>+</sup> memory B cells to mediate humoral immune evasion.","description":"Virus infections elicit long-term IgG antibody and memory responses. Human cytomegalovirus (HCMV) is widespread in humans and disseminates despite the presence of virus-specific antibodies. Here, we report that the HCMV Fcγ-binding glycoprotein 34 modulates humoral immunity by binding to IgG⁺ memory B cells. gp34-B cell receptor (BCR) interaction initiates activation of the PDK1/AKT/mTOR/S6 pathway and BCR internalization in a SYK-independent manner. Prolonged stimulation also induces B-cell activation via upregulation of CD69 and CD86. In a T-cell-dependent response, however, interaction with gp34 blocks B-cell proliferation, differentiation into plasmablasts, and soluble IgG production, while stimulating TNF-α secretion. Through gp34 stimulation on IgG⁺ B cells, neighboring IgM⁺ and IgA⁺","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T22:16:18.715Z","creation":"2026-07-09T10:18:58.439Z"},"accession":"S-EPMC12905349","cross_references":{"pubmed":["41559372"],"doi":["10.1038/s44321-026-00372-1"]}}