biostudies-literatureZheng MNational Natural Science Foundation of ChinaNational Natural Science Foundation of China (National Science Foundation of China)1619https://www.ebi.ac.uk/biostudies/studies/S-EPMC12905375biostudies-literatureUnknown17(1)The co-contamination of arsenite (As^III) and cadmium (Cd²⁺) poses a significant challenge in environmental remediation due to their divergent chemical speciation and transformation pathways. Here, a redox-active layered double oxide (MgMn-LDO) is designed, and achieves adsorption capacities of 821.7 mg g^‒1 for As^III and 1895.6 mg g^‒1 for Cd²⁺ in their coexisting system, presenting a state-of-the-art performance. Unexpectedly, the co-adsorption system not only enhances individual adsorption capacities but also accelerates the adsorption rate by 181‒fold compared to single-component systems. The LDO undergoes a four-stage spatiotemporally ordered topological transformation, which effectively decouples the oxidation of As<sup>INature communicationsSpatiotemporally ordered topological transformation in layered double hydroxides enables synergistic mineralization of As&lt;sup&gt;III&lt;/sup&gt;/Cd&lt;sup&gt;2&lt;/sup&gt;.PMC1290537522478027, 22438007, 22288102Xu SMCao XZheng MChen WDu HShi WShao MKong XDuan XfalseSpatiotemporally ordered topological transformation in layered double hydroxides enables synergistic mineralization of As&lt;sup&gt;III&lt;/sup&gt;/Cd&lt;sup&gt;2&lt;/sup&gt;.The co-contamination of arsenite (As^III) and cadmium (Cd²⁺) poses a significant challenge in environmental remediation due to their divergent chemical speciation and transformation pathways. Here, a redox-active layered double oxide (MgMn-LDO) is designed, and achieves adsorption capacities of 821.7 mg g^‒1 for As^III and 1895.6 mg g^‒1 for Cd²⁺ in their coexisting system, presenting a state-of-the-art performance. Unexpectedly, the co-adsorption system not only enhances individual adsorption capacities but also accelerates the adsorption rate by 181‒fold compared to single-component systems. The LDO undergoes a four-stage spatiotemporally ordered topological transformation, which effectively decouples the oxidation of As<sup>I2026-01-01T00:00:00Z2026 Jan2026-07-15T22:21:52.822Z2026-07-09T10:20:40.956ZS-EPMC129053754154542310.1038/s41467-026-68326-2