{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang D"],"funding":["China Postdoctoral Science Foundation","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12905451"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, and rapid aging. Repair and regeneration of aging skeletons are a global issue. Despite the self-healing ability of bone and the availability of various treatment strategies, degenerative bone repair and regeneration face significant problems due to unbalanced bone remodeling and a lack of active treatment strategies. The development of smart materials has created opportunities for degenerative bone repair and regeneration. The smart materials are responsive to endogenous/exogenous stimuli with tailored structure and function, which can promote skeletal aging repair and regeneration. Thus, in this study, skeletal aging is recognized as the progressive state that begins f"],"journal":["Bone research"],"pubmed_title":["Smart biomaterials for skeletal aging repair and regeneration."],"pmcid":["PMC12905451"],"funding_grant_id":["92468107","XJ2021051","82422045","82402814"],"pubmed_authors":["Xie Y","Qin K","Zhou T","Lin X","Wang H","Zhang L","Jiang Y","Ge S","Liang D","Zhang Z","Lyu H","Tan S","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Smart biomaterials for skeletal aging repair and regeneration.","description":"Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, and rapid aging. Repair and regeneration of aging skeletons are a global issue. Despite the self-healing ability of bone and the availability of various treatment strategies, degenerative bone repair and regeneration face significant problems due to unbalanced bone remodeling and a lack of active treatment strategies. The development of smart materials has created opportunities for degenerative bone repair and regeneration. The smart materials are responsive to endogenous/exogenous stimuli with tailored structure and function, which can promote skeletal aging repair and regeneration. Thus, in this study, skeletal aging is recognized as the progressive state that begins f","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T16:29:15.512Z","creation":"2026-07-07T03:08:10.883Z"},"accession":"S-EPMC12905451","cross_references":{"pubmed":["41688434"],"doi":["10.1038/s41413-026-00505-9"]}}