biostudies-literatureLiang DChina Postdoctoral Science FoundationNational Natural Science Foundation of China (National Science Foundation of China)24https://www.ebi.ac.uk/biostudies/studies/S-EPMC12905451biostudies-literatureUnknown14(1)Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, and rapid aging. Repair and regeneration of aging skeletons are a global issue. Despite the self-healing ability of bone and the availability of various treatment strategies, degenerative bone repair and regeneration face significant problems due to unbalanced bone remodeling and a lack of active treatment strategies. The development of smart materials has created opportunities for degenerative bone repair and regeneration. The smart materials are responsive to endogenous/exogenous stimuli with tailored structure and function, which can promote skeletal aging repair and regeneration. Thus, in this study, skeletal aging is recognized as the progressive state that begins fBone researchSmart biomaterials for skeletal aging repair and regeneration.PMC1290545192468107XJ20210518242204582402814Xie YQin KZhou TLin XWang HZhang LJiang YGe SLiang DZhang ZLyu HTan SWang YfalseSmart biomaterials for skeletal aging repair and regeneration.Skeletal aging associated with diverse age-related disorders is increasing due to unhealthy diets, stressful lifestyles, and rapid aging. Repair and regeneration of aging skeletons are a global issue. Despite the self-healing ability of bone and the availability of various treatment strategies, degenerative bone repair and regeneration face significant problems due to unbalanced bone remodeling and a lack of active treatment strategies. The development of smart materials has created opportunities for degenerative bone repair and regeneration. The smart materials are responsive to endogenous/exogenous stimuli with tailored structure and function, which can promote skeletal aging repair and regeneration. Thus, in this study, skeletal aging is recognized as the progressive state that begins f2026-01-01T00:00:00Z2026 Feb2026-07-15T16:29:15.512Z2026-07-07T03:08:10.883ZS-EPMC129054514168843410.1038/s41413-026-00505-9