{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu J"],"funding":["National Natural Science Foundation of China"],"pagination":["BCJ20253418"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12905490"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["483(2)"],"pubmed_abstract":["C-X-C motif chemokine ligand 17 (CXCL17) and its receptor G protein-coupled receptor 25 (GPR25) have been identified as a significant pair in regulating immunity, but CXCL17 orthologs have not yet been identified from non-mammalian vertebrates. This study aimed to identify and characterize non-mammalian CXCL17 orthologs based on key features of mammalian CXCL17s, such as a C-terminal Xaa-Pro-Yaa motif, a signal peptide, and six cysteine residues. Two possible CXCL17 paralogs were identified from zebrafish (Danio rerio): Dr-CXCL17 (encoded by zgc:158701) and Dr-CXCL17-like (encoded by si:dkey-112a7.5). Both are previously uncharacterized proteins with unknown functions because they lack overall sequence similarity to known mammalian CXCL17s. For functional characterization, recombinant Dr-C"],"journal":["The Biochemical journal"],"pubmed_title":["Identification and functional characterization of two CXCL17 paralogs from zebrafish."],"pmcid":["PMC12905490"],"funding_grant_id":["31971193"],"pubmed_authors":["Guo ZY","Liu YL","Yu J","Wang JJ","Xu ZG","Hu WF"],"additional_accession":[]},"is_claimable":false,"name":"Identification and functional characterization of two CXCL17 paralogs from zebrafish.","description":"C-X-C motif chemokine ligand 17 (CXCL17) and its receptor G protein-coupled receptor 25 (GPR25) have been identified as a significant pair in regulating immunity, but CXCL17 orthologs have not yet been identified from non-mammalian vertebrates. This study aimed to identify and characterize non-mammalian CXCL17 orthologs based on key features of mammalian CXCL17s, such as a C-terminal Xaa-Pro-Yaa motif, a signal peptide, and six cysteine residues. Two possible CXCL17 paralogs were identified from zebrafish (Danio rerio): Dr-CXCL17 (encoded by zgc:158701) and Dr-CXCL17-like (encoded by si:dkey-112a7.5). Both are previously uncharacterized proteins with unknown functions because they lack overall sequence similarity to known mammalian CXCL17s. For functional characterization, recombinant Dr-C","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T21:27:38.716Z","creation":"2026-07-09T10:14:19.148Z"},"accession":"S-EPMC12905490","cross_references":{"pubmed":["41521655"],"doi":["10.1042/BCJ20253418"]}}