{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(4)"],"submitter":["Zhang X"],"pubmed_abstract":["Insufficient infiltration or dysfunction of lymphocytes in the tumor immune microenvironment is considered to be a contributing factor to poor immunotherapy outcomes in solid tumors. Necroptosis, a form of immunogenic cell death, has attracted increasing interest because of its unique role in regulating tumor immune responses. CL-387785, a third-generation EGFR inhibitor, has been reported to inhibit tumors by regulating the cell cycle and inducing apoptosis; however, the underlying mechanisms remain unclear. In this study, we demonstrated that CL-387785 effectively suppressed the malignant phenotype of melanoma and lung cancer and confirmed that cancer cells undergo necroptosis, as evidenced by morphological and protein-level analyses. Further in vivo and in vitro experiments revealed tha"],"journal":["International journal of biological sciences"],"pagination":["2085-2100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12905644"],"repository":["biostudies-literature"],"pubmed_title":["Targeted Induction of Cancer Cell Necroptosis Potentiates Anti-PD-1 Immunotherapy via CD80 Activation."],"pmcid":["PMC12905644"],"pubmed_authors":["Zhang D","Zhang X","Peng C","Xiong S","Chen X","Zhou Z","Liu W","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Targeted Induction of Cancer Cell Necroptosis Potentiates Anti-PD-1 Immunotherapy via CD80 Activation.","description":"Insufficient infiltration or dysfunction of lymphocytes in the tumor immune microenvironment is considered to be a contributing factor to poor immunotherapy outcomes in solid tumors. Necroptosis, a form of immunogenic cell death, has attracted increasing interest because of its unique role in regulating tumor immune responses. CL-387785, a third-generation EGFR inhibitor, has been reported to inhibit tumors by regulating the cell cycle and inducing apoptosis; however, the underlying mechanisms remain unclear. In this study, we demonstrated that CL-387785 effectively suppressed the malignant phenotype of melanoma and lung cancer and confirmed that cancer cells undergo necroptosis, as evidenced by morphological and protein-level analyses. Further in vivo and in vitro experiments revealed tha","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-15T22:19:08.729Z","creation":"2026-07-09T10:20:30.463Z"},"accession":"S-EPMC12905644","cross_references":{"pubmed":["41694588"],"doi":["10.7150/ijbs.121690"]}}