{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao X"],"funding":["Major research projects come from National Clinical Key Specialty","Scientific Research Project of University of South China","Special Funding for the Construction of Innovative Provinces in Hunan","Natural Science Foundation of Hunan Province","Postgraduate Scientific Research Innovation Project of University of South China","National Natural Science Foundation of China"],"pagination":["294"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12905972"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(1)"],"pubmed_abstract":["<h4>Background</h4>Tryptophan (TRP) metabolism is implicated in the pathogenesis of hepatic encephalopathy (HE). Abnormal TRP metabolites correlate with HE severity and may represent potential biomarkers. This study employed targeted metabolomics to characterize serum TRP metabolic profiles in patients with liver cirrhosis (LC) at different stages. Furthermore, a diagnostic model integrating clinical indicators was developed to facilitate the early detection of hepatic encephalopathy in LC patients.<h4>Method</h4>Ninety LC patients (25 without HE, 30 with covert HE, and 35 with overt HE) and 50 healthy controls were enrolled from January 2023 to December 2024. Serum TRP metabolites were quantified using targeted liquid chromatography-mass spectrometry (LC-MS). A diagnostic model was develo"],"journal":["European journal of medical research"],"pubmed_title":["Development of a tryptophan metabolomics-based diagnostic model for hepatic encephalopathy in liver cirrhosis."],"pmcid":["PMC12905972"],"funding_grant_id":["Z2023081，Z2023158","82570697","2021SK4031","2024JJ5362, 2024JJ9401, 2025JJ81075，2025JJ81085，2023JJ60370","233YXC046"],"pubmed_authors":["Cao X","Hu Y","Ning L","Fu N","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Development of a tryptophan metabolomics-based diagnostic model for hepatic encephalopathy in liver cirrhosis.","description":"<h4>Background</h4>Tryptophan (TRP) metabolism is implicated in the pathogenesis of hepatic encephalopathy (HE). Abnormal TRP metabolites correlate with HE severity and may represent potential biomarkers. This study employed targeted metabolomics to characterize serum TRP metabolic profiles in patients with liver cirrhosis (LC) at different stages. Furthermore, a diagnostic model integrating clinical indicators was developed to facilitate the early detection of hepatic encephalopathy in LC patients.<h4>Method</h4>Ninety LC patients (25 without HE, 30 with covert HE, and 35 with overt HE) and 50 healthy controls were enrolled from January 2023 to December 2024. Serum TRP metabolites were quantified using targeted liquid chromatography-mass spectrometry (LC-MS). A diagnostic model was develo","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T16:35:43.21Z","creation":"2026-07-07T03:08:03.228Z"},"accession":"S-EPMC12905972","cross_references":{"pubmed":["41559838"],"doi":["10.1186/s40001-026-03863-6"]}}