biostudies-literatureUnknown67Marincek F<h4>Background</h4><i>Streptococcus pneumoniae</i> (the pneumococcus) is one of the main causes of childhood mortality. Understanding pneumococcal serotype and lineage distribution in children is important for vaccine decision-making. We undertook a secondary analysis of nasopharyngeal swabs collected from unvaccinated children as part of pneumococcal vaccine studies to provide a comprehensive picture of pneumococcal carriage epidemiology in Vietnamese children during the first 60 months of life.<h4>Methods</h4>We analysed 4375 nasopharyngeal swabs from unvaccinated children to assess overall and vaccine-type pneumococcal carriage at 6, 12, 18, 24, and 60 months of age. For the latter three age groups, serotype distribution and genetic lineages (Global Pneumococcal Sequence Cluster, GPSCs)The Lancet regional health. Western Pacific101805https://www.ebi.ac.uk/biostudies/studies/S-EPMC12906029biostudies-literature&lt;i&gt;Streptococcus pneumoniae&lt;/i&gt; nasopharyngeal carriage in Vietnamese children during the first five years of life: a post hoc analysis.PMC12906029Tran HPMulholland KSmith-Vaughan HTran HNManna SSatzke CLoc Thuy HNTran PLHinds JWee-Hee ATuong Le VTSpry LNguyen CNguyen TVDoan UYTrang Dai VTBright KTemple BBeissbarth JVan Phan TMarincek FPell COrtika Bfalse&lt;i&gt;Streptococcus pneumoniae&lt;/i&gt; nasopharyngeal carriage in Vietnamese children during the first five years of life: a post hoc analysis.<h4>Background</h4><i>Streptococcus pneumoniae</i> (the pneumococcus) is one of the main causes of childhood mortality. Understanding pneumococcal serotype and lineage distribution in children is important for vaccine decision-making. We undertook a secondary analysis of nasopharyngeal swabs collected from unvaccinated children as part of pneumococcal vaccine studies to provide a comprehensive picture of pneumococcal carriage epidemiology in Vietnamese children during the first 60 months of life.<h4>Methods</h4>We analysed 4375 nasopharyngeal swabs from unvaccinated children to assess overall and vaccine-type pneumococcal carriage at 6, 12, 18, 24, and 60 months of age. For the latter three age groups, serotype distribution and genetic lineages (Global Pneumococcal Sequence Cluster, GPSCs)2026-01-01T00:00:00Z2026 Feb2026-07-15T16:31:47.376Z2026-07-07T03:08:33.577ZS-EPMC129060294169523810.1016/j.lanwpc.2026.101805