{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Ni S"],"pubmed_abstract":["The circadian clock coordinates diverse biological processes to maintain physiological function and homeostasis in mammals under the day-night light cycle. Disruption of circadian rhythms impairs immune and metabolic functions and increases susceptibility to various diseases. Here, we demonstrate that long-term rest-phase time-restricted feeding (TRF), which disrupts circadian rhythmicity, induces bone loss and gut microbiota dysbiosis in male mice. Fecal microbiota transplantation (FMT) from circadian-misaligned feeding donors to germ-free recipients increased Th17 cell populations, thereby promoting the fusion of osteomorphs-a recently identified osteoclast precursor-into mature osteoclasts through the RANKL-RANK-OPG signaling pathway. Collectively, our findings identify a gut microbiota"],"journal":["Current research in microbial sciences"],"pagination":["100561"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12906124"],"repository":["biostudies-literature"],"pubmed_title":["Circadian rhythms regulate osteoclast recycling through gut microbiota-dependent Th17 cell expansion."],"pmcid":["PMC12906124"],"pubmed_authors":["Li X","Zhang Z","Fu W","Ni S","Zhang L"],"additional_accession":[]},"is_claimable":false,"name":"Circadian rhythms regulate osteoclast recycling through gut microbiota-dependent Th17 cell expansion.","description":"The circadian clock coordinates diverse biological processes to maintain physiological function and homeostasis in mammals under the day-night light cycle. Disruption of circadian rhythms impairs immune and metabolic functions and increases susceptibility to various diseases. Here, we demonstrate that long-term rest-phase time-restricted feeding (TRF), which disrupts circadian rhythmicity, induces bone loss and gut microbiota dysbiosis in male mice. Fecal microbiota transplantation (FMT) from circadian-misaligned feeding donors to germ-free recipients increased Th17 cell populations, thereby promoting the fusion of osteomorphs-a recently identified osteoclast precursor-into mature osteoclasts through the RANKL-RANK-OPG signaling pathway. Collectively, our findings identify a gut microbiota","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-15T22:15:27.753Z","creation":"2026-07-09T10:20:36.662Z"},"accession":"S-EPMC12906124","cross_references":{"pubmed":["41695578"],"doi":["10.1016/j.crmicr.2026.100561"]}}