biostudies-literatureUnknown52Yu SC<h4>Background</h4>Treatment response in first-episode psychosis (FEP) is highly variable, and reliable biomarkers for poor outcomes remain limited. MicroRNAs (miRNAs), important post-transcriptional regulators, have been implicated in psychotic disorders. However, genome-wide miRNA profiling and analyses of their downstream gene networks related to treatment response in FEP remain insufficiently explored.<h4>Methods</h4>We analyzed baseline miRNA expression in peripheral blood mononuclear cells from 41 antipsychotic-naïve or minimally treated FEP patients with six-month follow-up. Patients were classified as good (n = 17) or poor responders (n = 24) based on ≥20% symptom improvement on the Positive and Negative Syndrome Scale. Differentially expressed miRNAs were identified by microarray.Brain, behavior, & immunity - health101190https://www.ebi.ac.uk/biostudies/studies/S-EPMC12906215biostudies-literatureDysregulated miRNAs and downstream gene expression associated with poor treatment response in first-episode psychosis.PMC12906215Lin YTWang JPJen YWChien YLLiu CCWang YCYu SLWang CKuo PHYu SCYang TTHwang TJHsieh MHChen HYLin HPChan HYKuo CJShih YWChen WJLiu CMfalseDysregulated miRNAs and downstream gene expression associated with poor treatment response in first-episode psychosis.<h4>Background</h4>Treatment response in first-episode psychosis (FEP) is highly variable, and reliable biomarkers for poor outcomes remain limited. MicroRNAs (miRNAs), important post-transcriptional regulators, have been implicated in psychotic disorders. However, genome-wide miRNA profiling and analyses of their downstream gene networks related to treatment response in FEP remain insufficiently explored.<h4>Methods</h4>We analyzed baseline miRNA expression in peripheral blood mononuclear cells from 41 antipsychotic-naïve or minimally treated FEP patients with six-month follow-up. Patients were classified as good (n = 17) or poor responders (n = 24) based on ≥20% symptom improvement on the Positive and Negative Syndrome Scale. Differentially expressed miRNAs were identified by microarray.2026-01-01T00:00:00Z2026 Mar2026-07-15T22:11:44.795Z2026-07-09T10:20:39.846ZS-EPMC129062154169423210.1016/j.bbih.2026.101190