{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Yodying H"],"pubmed_abstract":["<h4>Background</h4>Delayed bleeding remains the most common adverse event after gastric endoscopic submucosal dissection (ESD). We assessed whether prophylactic mechanical closure is associated with reduced clinically significant delayed bleeding.<h4>Methods</h4>PubMed, Embase, Cochrane CENTRAL, Scopus, and ClinicalTrials.gov were searched through October 2025. Comparative studies reporting delayed bleeding within 30 days were included. Random-effects meta-analysis with Hartung-Knapp-Sidik-Jonkman adjustment was applied. Evidence certainty was assessed using GRADE.<h4>Results</h4>Nine studies (2646 patients; eight non-randomized) met inclusion criteria. Prophylactic closure was associated with reduced delayed bleeding (risk ratio [RR] 0.36, 95% confidence interval [CI] 0.16-0.82; <i>p</i> "],"journal":["DEN open"],"pagination":["e70299"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12906296"],"repository":["biostudies-literature"],"pubmed_title":["Prophylactic Mechanical Closure for Preventing Delayed Bleeding after Gastric Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis."],"pmcid":["PMC12906296"],"pubmed_authors":["Prapasajchavet W","Boonsinsukh T","Petchkaewkul P","Laojanun R","Rookkachart T","Sathornviriyapong S","Mekrugsakit N","Chartkitcharoen A","Viriyaroj V","Yodying H"],"additional_accession":[]},"is_claimable":false,"name":"Prophylactic Mechanical Closure for Preventing Delayed Bleeding after Gastric Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis.","description":"<h4>Background</h4>Delayed bleeding remains the most common adverse event after gastric endoscopic submucosal dissection (ESD). We assessed whether prophylactic mechanical closure is associated with reduced clinically significant delayed bleeding.<h4>Methods</h4>PubMed, Embase, Cochrane CENTRAL, Scopus, and ClinicalTrials.gov were searched through October 2025. Comparative studies reporting delayed bleeding within 30 days were included. Random-effects meta-analysis with Hartung-Knapp-Sidik-Jonkman adjustment was applied. Evidence certainty was assessed using GRADE.<h4>Results</h4>Nine studies (2646 patients; eight non-randomized) met inclusion criteria. Prophylactic closure was associated with reduced delayed bleeding (risk ratio [RR] 0.36, 95% confidence interval [CI] 0.16-0.82; <i>p</i> ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Apr","modification":"2026-07-15T22:15:54.761Z","creation":"2026-07-09T10:20:53.785Z"},"accession":"S-EPMC12906296","cross_references":{"pubmed":["41693739"],"doi":["10.1002/deo2.70299"]}}