{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu Y"],"funding":["Ninth People's Hospital, Shanghai Jiao-Tong University School of Medicine","Clinical Research Program of 9th People's Hospital affiliated to Shanghai Jiao-Tong University School of Medicine"],"pagination":["e71606"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12906978"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["<h4>Background</h4>Hepatic involvement is a life-threatening complication in natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis (NK/T-HLH). Nevertheless, the prognostic implications of hepatic dysfunction and its underlying related factors are not fully elucidated.<h4>Methods</h4>We retrospectively analyzed the clinical and laboratory data of 53 NK/T patients, comprising 35 cases without HLH and 18 with HLH. All NK/T-HLH patients exhibited hepatic injury, characterized by significantly elevated hepatic enzyme levels and bilirubin compared to those without HLH (all p < 0.001). Glutamyltransferase (GGT), aspartate aminotransferase (AST), and direct bilirubin (DBIL) individually predicted mortality with AUC > 0.8 in NKTCL patients, while their composite GSD index enhanced "],"journal":["Cancer medicine"],"pubmed_title":["IFN-γ Driven Hepatic Injury Exacerbates Mortality in NK/T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis."],"pmcid":["PMC12906978"],"funding_grant_id":["JYLJ202213","YJXKB202005"],"pubmed_authors":["Liu J","Ma L","Lu W","Shi J","Hang H","Pang Y","Zhou H","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"IFN-γ Driven Hepatic Injury Exacerbates Mortality in NK/T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis.","description":"<h4>Background</h4>Hepatic involvement is a life-threatening complication in natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis (NK/T-HLH). Nevertheless, the prognostic implications of hepatic dysfunction and its underlying related factors are not fully elucidated.<h4>Methods</h4>We retrospectively analyzed the clinical and laboratory data of 53 NK/T patients, comprising 35 cases without HLH and 18 with HLH. All NK/T-HLH patients exhibited hepatic injury, characterized by significantly elevated hepatic enzyme levels and bilirubin compared to those without HLH (all p < 0.001). Glutamyltransferase (GGT), aspartate aminotransferase (AST), and direct bilirubin (DBIL) individually predicted mortality with AUC > 0.8 in NKTCL patients, while their composite GSD index enhanced ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T15:43:18.457Z","creation":"2026-07-06T03:12:29.792Z"},"accession":"S-EPMC12906978","cross_references":{"pubmed":["41692467"],"doi":["10.1002/cam4.71606"]}}