biostudies-literatureYu YNinth People's Hospital, Shanghai Jiao-Tong University School of MedicineClinical Research Program of 9th People's Hospital affiliated to Shanghai Jiao-Tong University School of Medicinee71606https://www.ebi.ac.uk/biostudies/studies/S-EPMC12906978biostudies-literatureUnknown15(2)<h4>Background</h4>Hepatic involvement is a life-threatening complication in natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis (NK/T-HLH). Nevertheless, the prognostic implications of hepatic dysfunction and its underlying related factors are not fully elucidated.<h4>Methods</h4>We retrospectively analyzed the clinical and laboratory data of 53 NK/T patients, comprising 35 cases without HLH and 18 with HLH. All NK/T-HLH patients exhibited hepatic injury, characterized by significantly elevated hepatic enzyme levels and bilirubin compared to those without HLH (all p < 0.001). Glutamyltransferase (GGT), aspartate aminotransferase (AST), and direct bilirubin (DBIL) individually predicted mortality with AUC > 0.8 in NKTCL patients, while their composite GSD index enhanced Cancer medicineIFN-γ Driven Hepatic Injury Exacerbates Mortality in NK/T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis.PMC12906978JYLJ202213YJXKB202005Liu JMa LLu WShi JHang HPang YZhou HYu YfalseIFN-γ Driven Hepatic Injury Exacerbates Mortality in NK/T-Cell Lymphoma-Associated Hemophagocytic Lymphohistiocytosis.<h4>Background</h4>Hepatic involvement is a life-threatening complication in natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis (NK/T-HLH). Nevertheless, the prognostic implications of hepatic dysfunction and its underlying related factors are not fully elucidated.<h4>Methods</h4>We retrospectively analyzed the clinical and laboratory data of 53 NK/T patients, comprising 35 cases without HLH and 18 with HLH. All NK/T-HLH patients exhibited hepatic injury, characterized by significantly elevated hepatic enzyme levels and bilirubin compared to those without HLH (all p < 0.001). Glutamyltransferase (GGT), aspartate aminotransferase (AST), and direct bilirubin (DBIL) individually predicted mortality with AUC > 0.8 in NKTCL patients, while their composite GSD index enhanced 2026-01-01T00:00:00Z2026 Feb2026-07-15T15:43:18.457Z2026-07-06T03:12:29.792ZS-EPMC129069784169246710.1002/cam4.71606