{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopez-Sampere Y"],"funding":["Carlos III Health Institute","Fundación Ramón Areces","Xarxa de Bancs de Tumors de Catalunya"],"pagination":["104068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907107"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91"],"pubmed_abstract":["<h4>Background</h4>Nuclear factor erythroid 2-related factor 2 (NRF2) regulates antioxidant defenses and protects against neurodegeneration, including Alzheimer's disease (AD). Its age-related decline disrupts redox balance and increases neuronal vulnerability, but the early hippocampal effects remain unclear. Here, we tested whether NRF2 loss affects tau seeding and spreading in a PHF-tau-inoculated mouse model, contributing to accelerated aging.<h4>Methodology</h4>Three-month-old NRF2-knockout (Nfe2l2<sup>-/-</sup>) and wild-type (WT) mice received hippocampal inoculations of human AD-derived PHF-tau, and tau propagation was analyzed after three months. To elucidate the molecular underpinnings of the observed changes, we performed integrative phosphoproteotranscriptomic analyses of hippo"],"journal":["Redox biology"],"pubmed_title":["NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model."],"pmcid":["PMC12907107"],"funding_grant_id":["PT20/00171","PI23/00176","CD23/00097","PI20/000155"],"pubmed_authors":["Vinyals A","Dakterzada F","Del Rio JA","Roca-Pereira S","Santamaria E","Romero L","Vela-Martinez M","Portero-Otin M","Andres-Benito P","Pinol-Ripoll G","Mato-Blanco X","Ferrer I","Fernandez-Irigoyen J","Santpere G","Povedano M","Mengod Soler P","Lopez-Sampere Y"],"additional_accession":[]},"is_claimable":false,"name":"NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model.","description":"<h4>Background</h4>Nuclear factor erythroid 2-related factor 2 (NRF2) regulates antioxidant defenses and protects against neurodegeneration, including Alzheimer's disease (AD). Its age-related decline disrupts redox balance and increases neuronal vulnerability, but the early hippocampal effects remain unclear. Here, we tested whether NRF2 loss affects tau seeding and spreading in a PHF-tau-inoculated mouse model, contributing to accelerated aging.<h4>Methodology</h4>Three-month-old NRF2-knockout (Nfe2l2<sup>-/-</sup>) and wild-type (WT) mice received hippocampal inoculations of human AD-derived PHF-tau, and tau propagation was analyzed after three months. To elucidate the molecular underpinnings of the observed changes, we performed integrative phosphoproteotranscriptomic analyses of hippo","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-15T21:30:11.849Z","creation":"2026-07-09T10:13:58.831Z"},"accession":"S-EPMC12907107","cross_references":{"pubmed":["41650822"],"doi":["10.1016/j.redox.2026.104068"]}}