{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(2)"],"submitter":["Pu L"],"pubmed_abstract":["Centenarians, individuals who reach extreme old age, provide a valuable model for understanding mechanisms associated with healthy aging. Using ATAC-seq and transcriptomic profiling of peripheral blood mononuclear cells from centenarians, we identified a distinct chromatin accessibility landscape linked to exceptional longevity. Integrative analysis highlighted the E-26 transformation-specific (ETS)-related transcription factor ERG as a longevity-associated regulator. Functional studies in human cells showed that ERG forms nuclear condensates through liquid-liquid phase separation, a property associated with altered chromatin organization and reduced expression of senescence-related genes, including CDKN2A. Consistent with these effects, ERG condensation was associated with attenuation of "],"journal":["iScience"],"pagination":["114678"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907116"],"repository":["biostudies-literature"],"pubmed_title":["ERG phase separation attenuates cellular senescence."],"pmcid":["PMC12907116"],"pubmed_authors":["Zhou L","Li H","Zuo Z","Chen J","Jiang H","Ge M","Qi S","Zhao Y","Gao R","Hu F","Zheng H","Jin H","Pu L","Deng Z","Ou R","Xiao C","Wu X","Dong B"],"additional_accession":[]},"is_claimable":false,"name":"ERG phase separation attenuates cellular senescence.","description":"Centenarians, individuals who reach extreme old age, provide a valuable model for understanding mechanisms associated with healthy aging. Using ATAC-seq and transcriptomic profiling of peripheral blood mononuclear cells from centenarians, we identified a distinct chromatin accessibility landscape linked to exceptional longevity. Integrative analysis highlighted the E-26 transformation-specific (ETS)-related transcription factor ERG as a longevity-associated regulator. Functional studies in human cells showed that ERG forms nuclear condensates through liquid-liquid phase separation, a property associated with altered chromatin organization and reduced expression of senescence-related genes, including CDKN2A. Consistent with these effects, ERG condensation was associated with attenuation of ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T05:04:40.162Z","creation":"2026-07-09T10:37:30.493Z"},"accession":"S-EPMC12907116","cross_references":{"pubmed":["41704762"],"doi":["10.1016/j.isci.2026.114678"]}}