{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Pangrazzi L"],"pubmed_abstract":["Naïve CD8+ T cells are key players of adaptive immunity, but their heterogeneity and age-related changes are not fully understood. This study aimed to compare naïve CD8+ T cell subsets defined by different combinations of markers, namely, NCCR7 (CD45RA+CCR7+), NCD28 (CD45RA+CD28+), NCD27 (CD45RA+CD27+), and phenotypically most \"true-naïve\"-like, NTN (CD45RA+CCR7+CD28+CD27+CD57-). Peripheral blood was harvested from donors of various ages and the phenotype of the four subsets of naïve CD8+ T cells was analyzed. NCD27 and NTN cells showed similar phenotypes with low expressio"],"journal":["Frontiers in aging"],"pagination":["1765665"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907349"],"repository":["biostudies-literature"],"pubmed_title":["Phenotypic and functional heterogeneity of naive CD8<sup>+</sup> T cells in human peripheral blood during aging."],"pmcid":["PMC12907349"],"pubmed_authors":["Chelini G","Bachmann M","Pangrazzi L","Hoffmann L","Jenewein B","Weinberger B","Pehl P","Keller M","Cavinato M"],"additional_accession":[]},"is_claimable":false,"name":"Phenotypic and functional heterogeneity of naive CD8<sup>+</sup> T cells in human peripheral blood during aging.","description":"Naïve CD8+ T cells are key players of adaptive immunity, but their heterogeneity and age-related changes are not fully understood. This study aimed to compare naïve CD8+ T cell subsets defined by different combinations of markers, namely, NCCR7 (CD45RA+CCR7+), NCD28 (CD45RA+CD28+), NCD27 (CD45RA+CD27+), and phenotypically most \"true-naïve\"-like, NTN (CD45RA+CCR7+CD28+CD27+CD57-). Peripheral blood was harvested from donors of various ages and the phenotype of the four subsets of naïve CD8+ T cells was analyzed. NCD27 and NTN cells showed similar phenotypes with low expressio","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-10T03:11:51.422Z","creation":"2026-07-10T03:08:43.715Z"},"accession":"S-EPMC12907349","cross_references":{"pubmed":["41704679"],"doi":["10.3389/fragi.2026.1765665"]}}