{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Frontiers diagnosis and treatment of liver cancer innovation team","National Natural Science Foundation of China","health commission of hunan province","Leading Talents in Science and Technology Innovation in Hunan Province","Natural Science Fund for Outstanding Young Scholars of Hunan Province"],"pagination":["17588359251413942"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18"],"pubmed_abstract":["<h4>Background</h4>Spontaneous tumor rupture is a unique and life-threatening presentation of hepatocellular carcinoma (HCC). The optimal postoperative management of patients with spontaneously ruptured HCC (srHCC) remains controversial. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been proposed to reduce peritoneal dissemination, but its clinical benefit in srHCC is uncertain.<h4>Objectives</h4>This study aimed to evaluate the survival benefit and safety of postoperative HIPEC combined with hepatic resection in patients with srHCC.<h4>Design</h4>A retrospective multicenter cohort study was conducted, including patients with srHCC who underwent curative hepatectomy with or without postoperative HIPEC between 2018 and 2024.<h4>Methods</h4>A total of 208 srHCC patients from 4 instit"],"journal":["Therapeutic advances in medical oncology"],"pubmed_title":["Resection combined with hyperthermic intraperitoneal chemotherapy in the treatment of spontaneously ruptured hepatocellular carcinoma: a multicenter retrospective study."],"pmcid":["PMC12907485"],"funding_grant_id":["KCT202404","Z2023031","22374045","2024RC1051","2024JJ2037","82303186"],"pubmed_authors":["Li Y","Fu S","Fei S","Feng Z","Sun B","Peng C","Liu S","Yi W","Tang Y","Song Y","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Resection combined with hyperthermic intraperitoneal chemotherapy in the treatment of spontaneously ruptured hepatocellular carcinoma: a multicenter retrospective study.","description":"<h4>Background</h4>Spontaneous tumor rupture is a unique and life-threatening presentation of hepatocellular carcinoma (HCC). The optimal postoperative management of patients with spontaneously ruptured HCC (srHCC) remains controversial. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been proposed to reduce peritoneal dissemination, but its clinical benefit in srHCC is uncertain.<h4>Objectives</h4>This study aimed to evaluate the survival benefit and safety of postoperative HIPEC combined with hepatic resection in patients with srHCC.<h4>Design</h4>A retrospective multicenter cohort study was conducted, including patients with srHCC who underwent curative hepatectomy with or without postoperative HIPEC between 2018 and 2024.<h4>Methods</h4>A total of 208 srHCC patients from 4 instit","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-16T04:57:04.587Z","creation":"2026-07-09T13:09:45.688Z"},"accession":"S-EPMC12907485","cross_references":{"pubmed":["41705140"],"doi":["10.1177/17588359251413942"]}}