biostudies-literatureUnknown58Wurschi GW<h4>Introduction</h4>Complete response (CR) after total neoadjuvant therapy (TNT) in rectal cancer is linked to favorable local control and enables non-operative management (NOM). Achieving high CR rates is crucial. As no standard TNT protocol exists, we aimed to assess the impact of clinical factors and different protocols on CR rates.<h4>Methods</h4>Rectal cancer patients undergoing TNT with curative intent between 2015 and 2024 were included in this retrospective multicenter analysis (DRKS00033000). The primary endpoint was CR. Predefined clinical and therapeutic variables were treated as covariates and evaluated as potential predictors of CR in a multivariable logistic regression model.<h4>Results</h4>Among 245 included patients (181 men) with a median age of 62 (Q1-Q3: 54-67) years, 1Clinical and translational radiation oncology101120https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907501biostudies-literatureClinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis.PMC12907501Schunn FKessler CRißner FSahin ECHa HMFabian ARomer MVorbach SMBeier JEhret Fvon Gruben MEFerdinandus SSonnhoff MWurschi GWAninditha Kvon Ohlen DSButtner MKaufmann JSchneider MDiefenhardt MFrerker BTrommer SRuhle ABecker JNHoffmann ECieslak ATrommer MHlouschek JPietschmann KDepardon AfalseClinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis.<h4>Introduction</h4>Complete response (CR) after total neoadjuvant therapy (TNT) in rectal cancer is linked to favorable local control and enables non-operative management (NOM). Achieving high CR rates is crucial. As no standard TNT protocol exists, we aimed to assess the impact of clinical factors and different protocols on CR rates.<h4>Methods</h4>Rectal cancer patients undergoing TNT with curative intent between 2015 and 2024 were included in this retrospective multicenter analysis (DRKS00033000). The primary endpoint was CR. Predefined clinical and therapeutic variables were treated as covariates and evaluated as potential predictors of CR in a multivariable logistic regression model.<h4>Results</h4>Among 245 included patients (181 men) with a median age of 62 (Q1-Q3: 54-67) years, 12026-01-01T00:00:00Z2026 May2026-07-16T05:10:05.786Z2026-07-10T03:09:32.85ZS-EPMC129075014170472010.1016/j.ctro.2026.101120