biostudies-literatureUnknown52Liu Z<h4>Background</h4>Autoimmunity is a key clinical feature in both post-infectious Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of COVID (PASC). Passive transfer of immunoglobulins from patients' sera into mice induces some clinical features of PASC. However, the physiological effects of immunoglobulins on cellular alterations remain elusive. In this study, we tested the potential effects of immunoglobulins from ME/CFS patients on endothelial cell dysfunction.<h4>Methods</h4>We have isolated immunoglobulins from 106 individuals, including ME/CFS (n = 39), PCS-CFS (n = 15), MS (n = 20) patients, and healthy controls (n = 41). Protein composition of the isolated immune complexes was studied using mass spectrometry. The effect of isolated immune complexesBrain, behavior, & immunity - health101187https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907502biostudies-literatureImmunoglobulin G complexes from post-infectious ME/CFS, including post-COVID ME/CFS disrupt cellular energetics and alter inflammatory marker secretion.PMC12907502Hollmann CSotzny FRust RKalanidhi SSchlosser ANora-Krukle ZNaviaux RKLiu ZRiemekasten GBasens EELamer SSokolovska LNikolayshvili GScheibenbogen CBellmann-Strobl JPrusty BKPaul FfalseImmunoglobulin G complexes from post-infectious ME/CFS, including post-COVID ME/CFS disrupt cellular energetics and alter inflammatory marker secretion.<h4>Background</h4>Autoimmunity is a key clinical feature in both post-infectious Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Post-Acute Sequelae of COVID (PASC). Passive transfer of immunoglobulins from patients' sera into mice induces some clinical features of PASC. However, the physiological effects of immunoglobulins on cellular alterations remain elusive. In this study, we tested the potential effects of immunoglobulins from ME/CFS patients on endothelial cell dysfunction.<h4>Methods</h4>We have isolated immunoglobulins from 106 individuals, including ME/CFS (n = 39), PCS-CFS (n = 15), MS (n = 20) patients, and healthy controls (n = 41). Protein composition of the isolated immune complexes was studied using mass spectrometry. The effect of isolated immune complexes2026-01-01T00:00:00Z2026 Mar2026-07-16T04:57:15.688Z2026-07-09T13:09:49.131ZS-EPMC129075024170465910.1016/j.bbih.2026.101187