biostudies-literatureUnknown92Tabakovic N<h4>Background</h4>Cryptoglandular anal fistula is a condition that significantly impairs quality of life in patients. Despite the recent development of the Anal Fistula Core Outcome Set (AFCOS), which identified ten key outcomes, variation in outcome definitions and measurement instruments hampers comparability across studies and limits evidence synthesis. An essential final step to improve future comparability is the development of a Core Outcome Measurement Set (COMS) aligned with AFCOS; this study aimed to establish such a COMS through an international, consensus-driven process.<h4>Methods</h4>This study was conducted in three phases according to the Core Outcome Measures Effectiveness Trials (COMET) methodology. Phase 1 included a scoping review to identify definitions and measurementEClinicalMedicine103745https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907631biostudies-literatureCryptoglandular Anal Fistula Core Outcome Measurement Set (AFCOMS): standardised definitions and measurement instruments.PMC12907631Tozer PMarra AALung PJongen JWard SLopez-Alcalde JSenra FReza LLundby LAdeyeye AStrouhal RGallo GIsik AStijns JRocha RJoshi SGosselink MTamburini AMBreukink SAmbe PMitalas LAndriopoulou EGrainger JKimman MAFCOMS Consensus Meeting CollaboratorsLin AAlexandre FPata FSantoro GATabakovic NIqbal NBislenghi GfalseCryptoglandular Anal Fistula Core Outcome Measurement Set (AFCOMS): standardised definitions and measurement instruments.<h4>Background</h4>Cryptoglandular anal fistula is a condition that significantly impairs quality of life in patients. Despite the recent development of the Anal Fistula Core Outcome Set (AFCOS), which identified ten key outcomes, variation in outcome definitions and measurement instruments hampers comparability across studies and limits evidence synthesis. An essential final step to improve future comparability is the development of a Core Outcome Measurement Set (COMS) aligned with AFCOS; this study aimed to establish such a COMS through an international, consensus-driven process.<h4>Methods</h4>This study was conducted in three phases according to the Core Outcome Measures Effectiveness Trials (COMET) methodology. Phase 1 included a scoping review to identify definitions and measurement2026-01-01T00:00:00Z2026 Feb2026-07-16T05:13:01.735Z2026-07-09T10:37:44.665ZS-EPMC129076314170501710.1016/j.eclinm.2025.103745