{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["NIA NIH HHS"],"pagination":["1339-1350"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907878"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(5)"],"pubmed_abstract":["While parity is a significant factor influencing parental health, its relationship with dementia remains underexplored. This research note advances the literature by conducting a well-powered analysis of associations between parity (i.e., number of children) and Alzheimer's disease and dementias (AD/D) status in large-scale population data. The data contain a large number of AD/D cases (37,228 women and 19,846 men), allowing a range (1-10) of parity associations to be estimated precisely. Using proxy (adult child's) reports of parental AD/D status, we find that both fathers and mothers with grand multiparity have decreased odds of AD/D status, and the effect sizes become larger as parity increases, with 30-40% reduction in AD/D status at parities above 7. The association is stronger for mo"],"journal":["Demography"],"pubmed_title":["Research Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status."],"pmcid":["PMC12907878"],"funding_grant_id":["P30 AG017266","RF1 AG062765"],"pubmed_authors":["Zhang Y","Fletcher JM"],"additional_accession":[]},"is_claimable":false,"name":"Research Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status.","description":"While parity is a significant factor influencing parental health, its relationship with dementia remains underexplored. This research note advances the literature by conducting a well-powered analysis of associations between parity (i.e., number of children) and Alzheimer's disease and dementias (AD/D) status in large-scale population data. The data contain a large number of AD/D cases (37,228 women and 19,846 men), allowing a range (1-10) of parity associations to be estimated precisely. Using proxy (adult child's) reports of parental AD/D status, we find that both fathers and mothers with grand multiparity have decreased odds of AD/D status, and the effect sizes become larger as parity increases, with 30-40% reduction in AD/D status at parities above 7. The association is stronger for mo","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-15T21:29:20.968Z","creation":"2026-07-09T10:14:43.654Z"},"accession":"S-EPMC12907878","cross_references":{"pubmed":["39330980"],"doi":["10.1215/00703370-11585876"]}}