biostudies-literatureZhang YNIA NIH HHS1339-1350https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907878biostudies-literatureUnknown61(5)While parity is a significant factor influencing parental health, its relationship with dementia remains underexplored. This research note advances the literature by conducting a well-powered analysis of associations between parity (i.e., number of children) and Alzheimer's disease and dementias (AD/D) status in large-scale population data. The data contain a large number of AD/D cases (37,228 women and 19,846 men), allowing a range (1-10) of parity associations to be estimated precisely. Using proxy (adult child's) reports of parental AD/D status, we find that both fathers and mothers with grand multiparity have decreased odds of AD/D status, and the effect sizes become larger as parity increases, with 30-40% reduction in AD/D status at parities above 7. The association is stronger for moDemographyResearch Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status.PMC12907878P30 AG017266RF1 AG062765Zhang YFletcher JMfalseResearch Note: The Association Between Parity and Odds of Alzheimer's Disease and Dementias Status.While parity is a significant factor influencing parental health, its relationship with dementia remains underexplored. This research note advances the literature by conducting a well-powered analysis of associations between parity (i.e., number of children) and Alzheimer's disease and dementias (AD/D) status in large-scale population data. The data contain a large number of AD/D cases (37,228 women and 19,846 men), allowing a range (1-10) of parity associations to be estimated precisely. Using proxy (adult child's) reports of parental AD/D status, we find that both fathers and mothers with grand multiparity have decreased odds of AD/D status, and the effect sizes become larger as parity increases, with 30-40% reduction in AD/D status at parities above 7. The association is stronger for mo2024-01-01T00:00:00Z2024 Oct2026-07-15T21:29:20.968Z2026-07-09T10:14:43.654ZS-EPMC129078783933098010.1215/00703370-11585876