{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xia L"],"funding":["Natural Science Foundation of Anhui Province"],"pagination":["104007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91"],"pubmed_abstract":["<h4>Background</h4>Multiple myeloma (MM) is an incurable plasma cell malignancy with high relapse rate. Recent studies have implicated dysregulated autophagy and ferroptosis in MM progression; however, the molecular links remain elusive. This study investigated the role of SDE2, a ubiquitin-like protein overexpressed in MM, in modulating autophagy-ferroptosis crosstalk via ATG5 degradation with the aim of identifying novel therapeutic targets.<h4>Methods</h4>Using bioinformatic analysis of TCGA data, we identified SDE2 as a prognostic marker in MM. Functional validation included Western blot, co-immunoprecipitation, and ubiquitination assays in MM cell lines (H929, RPMI8226, OPM-2, and KMS-11) and patient-derived samples. Transwell migration, soft agar colony formation, and flow cytometry "],"journal":["Redox biology"],"pubmed_title":["Inhibition of SDE2 promotes autophagy-dependent ferroptosis in multiple myeloma."],"pmcid":["PMC12907901"],"funding_grant_id":["2023AH053319"],"pubmed_authors":["Zheng Y","Xia L","Bao J","Chen XW","Wang X","Zhao YC"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of SDE2 promotes autophagy-dependent ferroptosis in multiple myeloma.","description":"<h4>Background</h4>Multiple myeloma (MM) is an incurable plasma cell malignancy with high relapse rate. Recent studies have implicated dysregulated autophagy and ferroptosis in MM progression; however, the molecular links remain elusive. This study investigated the role of SDE2, a ubiquitin-like protein overexpressed in MM, in modulating autophagy-ferroptosis crosstalk via ATG5 degradation with the aim of identifying novel therapeutic targets.<h4>Methods</h4>Using bioinformatic analysis of TCGA data, we identified SDE2 as a prognostic marker in MM. Functional validation included Western blot, co-immunoprecipitation, and ubiquitination assays in MM cell lines (H929, RPMI8226, OPM-2, and KMS-11) and patient-derived samples. Transwell migration, soft agar colony formation, and flow cytometry ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T05:11:53.353Z","creation":"2026-07-09T10:36:46.293Z"},"accession":"S-EPMC12907901","cross_references":{"pubmed":["41666676"],"doi":["10.1016/j.redox.2026.104007"]}}