{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(2)"],"submitter":["Cosentino C"],"pubmed_abstract":["The clinical and biological significance of clonal hematopoiesis (CH) has not been investigated in the myeloid compartment of chronic lymphocytic leukemia (CLL). By studying 488 newly diagnosed CLL through CAPP-seq using a 28-gene panel on granulocyte genomic DNA (gDNA), CH occurred in 231 (47.3%) patients. Cell sorting of cases that never developed Richter transformation (RT) confirmed that CH mutations, including CH-related <i>TP53</i> mutations, were restricted to the myelomonocytic compartment and absent in CLL cells, as also documented by single-cell DNA sequencing. CH associated with shorter overall survival (OS) (hazard ratio [HR] 1.36, 95% CI 1.04-1.77, P = 0.023); specifically, <i>TET2</i> mutations independently predicted inferior OS (HR 1.62, 95% CI 1.15-2.28, P = 0.01) after ad"],"journal":["HemaSphere"],"pagination":["e70322"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907972"],"repository":["biostudies-literature"],"pubmed_title":["Dissecting clonal hematopoiesis in the myeloid compartment of chronic lymphocytic leukemia and Richter transformation."],"pmcid":["PMC12907972"],"pubmed_authors":["Lazzaro M","Ghanej J","Fumagalli L","Perutelli F","Terzi di Bergamo L","Rossi D","Foa R","Coscia M","Trentin L","Cardinali D","Cividini L","Kogila S","Mahmoud AM","Deambrogi C","Maiellaro F","Cosentino C","Iannelli F","Scarfo L","Vitale C","Ghia P","Salehi M","Maher N","Pileri S","Gattei V","Rasi S","Zucchetto A","Romano I","Secomandi E","Cappelli LV","Nawabi MR","Almasri M","Al Deeban B","Gaglio A","Chiarle R","Caneparo V","Visentin A","Nabki J","Griggio V","Mouhssine S","Bellia M","Del Giudice I","Nicolosi M","Albi E","Dondolin R","Gaidano G","Moia R"],"additional_accession":[]},"is_claimable":false,"name":"Dissecting clonal hematopoiesis in the myeloid compartment of chronic lymphocytic leukemia and Richter transformation.","description":"The clinical and biological significance of clonal hematopoiesis (CH) has not been investigated in the myeloid compartment of chronic lymphocytic leukemia (CLL). By studying 488 newly diagnosed CLL through CAPP-seq using a 28-gene panel on granulocyte genomic DNA (gDNA), CH occurred in 231 (47.3%) patients. Cell sorting of cases that never developed Richter transformation (RT) confirmed that CH mutations, including CH-related <i>TP53</i> mutations, were restricted to the myelomonocytic compartment and absent in CLL cells, as also documented by single-cell DNA sequencing. CH associated with shorter overall survival (OS) (hazard ratio [HR] 1.36, 95% CI 1.04-1.77, P = 0.023); specifically, <i>TET2</i> mutations independently predicted inferior OS (HR 1.62, 95% CI 1.15-2.28, P = 0.01) after ad","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T05:10:39.384Z","creation":"2026-07-09T10:36:38.36Z"},"accession":"S-EPMC12907972","cross_references":{"pubmed":["41704549"],"doi":["10.1002/hem3.70322"]}}