{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen H"],"funding":["Technology Planning Project of Linzhi","National Key Research and Development Program of China","Science and Technology Projects in Guangzhou","Guangdong S&T programme"],"pagination":["193-206"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907977"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["<h4>Background</h4>The aim of the study was to develop a non-human primate model of metabolic dysfunction in Macaca fascicularis using chronic high-fat diet (HFD) to mimic clinical disease progression.<h4>Methods</h4>Thirty-five male macaques aged 10-15 years underwent an 18-month HFD intervention. Physiological parameters (BMI, BP, hematology), liver fat fraction (evaluated by ultrasound/MRI), cardiac function (assessed by echocardiography), and histopathology (using liver biopsy) were measured before and after the intervention. Serum proteomics with KEGG/STRING analyses identified molecular mechanisms.<h4>Results</h4>Within 6 months, HFD induced dyslipidemia (elevated TG, TCHO, HDL-C, LDL-C). After 18 months, metabolic dysfunction-associated steatohepatitis (MASH) was confirmed by histop"],"journal":["Animal models and experimental medicine"],"pubmed_title":["Chronic high-fat diet induces multi-organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis."],"pmcid":["PMC12907977"],"funding_grant_id":["202206010197","2021YFF0702200","2023-YZ-01","202206010084","202206060002","2023B0303040004","2009A081000002"],"pubmed_authors":["Li G","Cai L","Chen H","Liu S","Jin Y","Liu W","Li X","Guan Y","Li Y","Huang Z","Zhang Y","Zhou D","Miao Z"],"additional_accession":[]},"is_claimable":false,"name":"Chronic high-fat diet induces multi-organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis.","description":"<h4>Background</h4>The aim of the study was to develop a non-human primate model of metabolic dysfunction in Macaca fascicularis using chronic high-fat diet (HFD) to mimic clinical disease progression.<h4>Methods</h4>Thirty-five male macaques aged 10-15 years underwent an 18-month HFD intervention. Physiological parameters (BMI, BP, hematology), liver fat fraction (evaluated by ultrasound/MRI), cardiac function (assessed by echocardiography), and histopathology (using liver biopsy) were measured before and after the intervention. Serum proteomics with KEGG/STRING analyses identified molecular mechanisms.<h4>Results</h4>Within 6 months, HFD induced dyslipidemia (elevated TG, TCHO, HDL-C, LDL-C). After 18 months, metabolic dysfunction-associated steatohepatitis (MASH) was confirmed by histop","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T16:24:47.324Z","creation":"2026-07-07T03:08:21.494Z"},"accession":"S-EPMC12907977","cross_references":{"pubmed":["41531306"],"doi":["10.1002/ame2.70124"]}}