biostudies-literatureUnknown25(1)Liu R<h4>Purpose</h4>To identify the specific risk factors associated with unexplained infertility (UI) among infertile couples.<h4>Methods</h4>We conducted a retrospective cohort study analyzing UI risk factors, focusing on 5465 infertile couples who completed their first full in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle out of a total cohort of 62201 infertile couples.<h4>Results</h4>Among 5465 UI couples, 3400 achieved a live birth (cumulative live birth rate = 62.2%). Multivariate logistic regression indicated the key negative predictors included: female age ≥ 35 years (odds ratio [OR]: 0.63; 95% confidence interval [CI]: 0.51-0.78; <i>p <</i> 0.001), male age (OR: 0.98; 95% CI: 0.96-0.99; <i>p =</i> 0.015), Female body mass index ≥ 27.5 kg/m² (OR: 0.78; 95% CI: 0.62-0.97; <i>p =</i> 0.028), low anti-Müllerian hormone (AMH) (AMH < 1.2 ng/mL) (OR: 0.64; 95% CI: 0.52-0.77; <i>p <</i> 0.001), and a mid-range endometrial thickness (EMT) (EMT 0.7-1.0 cm) (OR: 0.77; 95% CI: 0.66-0.89; <i>p <</i> 0.001). A higher number of retrieved oocytes positively correlated with cumulative live birth (CLB) (OR: 1.02; 95% CI: 1.01-1.04; <i>p =</i> 0.039).<h4>Conclusion</h4>The prevalence of UI was 8.8% in our population, with 62.2% achieving CLB after one complete IVF/ICSI cycle. Female age and ovarian reserve indicators emerged as the main factors influencing oocyte yield, embryo acquisition, and CLB outcomes in UI patients.Reproductive medicine and biologye70025https://www.ebi.ac.uk/biostudies/studies/S-EPMC12907981biostudies-literatureAnalysis of Risk Factors Affecting Cumulative Live Birth in Couples With Unexplained Infertility Undergoing IVF/ICSI.PMC12907981Ding GLiu RMa ZMa JWu TDang YSong YfalseAnalysis of Risk Factors Affecting Cumulative Live Birth in Couples With Unexplained Infertility Undergoing IVF/ICSI.<h4>Purpose</h4>To identify the specific risk factors associated with unexplained infertility (UI) among infertile couples.<h4>Methods</h4>We conducted a retrospective cohort study analyzing UI risk factors, focusing on 5465 infertile couples who completed their first full in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle out of a total cohort of 62201 infertile couples.<h4>Results</h4>Among 5465 UI couples, 3400 achieved a live birth (cumulative live birth rate = 62.2%). Multivariate logistic regression indicated the key negative predictors included: female age ≥ 35 years (odds ratio [OR]: 0.63; 95% confidence interval [CI]: 0.51-0.78; <i>p <</i> 0.001), male age (OR: 0.98; 95% CI: 0.96-0.99; <i>p =</i> 0.015), Female body mass index ≥ 27.5 kg/m² (OR: 0.78; 95% CI: 0.62-0.97; <i>p =</i> 0.028), low anti-Müllerian hormone (AMH) (AMH < 1.2 ng/mL) (OR: 0.64; 95% CI: 0.52-0.77; <i>p <</i> 0.001), and a mid-range endometrial thickness (EMT) (EMT 0.7-1.0 cm) (OR: 0.77; 95% CI: 0.66-0.89; <i>p <</i> 0.001). A higher number of retrieved oocytes positively correlated with cumulative live birth (CLB) (OR: 1.02; 95% CI: 1.01-1.04; <i>p =</i> 0.039).<h4>Conclusion</h4>The prevalence of UI was 8.8% in our population, with 62.2% achieving CLB after one complete IVF/ICSI cycle. Female age and ovarian reserve indicators emerged as the main factors influencing oocyte yield, embryo acquisition, and CLB outcomes in UI patients.2026-01-01T00:00:00Z2026 Jan-Dec2026-07-09T11:08:55.194Z2026-07-09T10:41:36.127ZS-EPMC129079814170527410.1002/rmb2.70025