{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shard C"],"funding":["The Kids Research Institute Australia Ascend","Cancer Council S.A. Beat Cancer Project","Charlie Teo Foundation","Cancer Council of Western Australia","Robert Connor Dawes Foundation","Western Australian Future Health Research and Innovation Fund","NHMRC","Perth Children's Hospital Foundation","McCleary Murchland Fellowship","Children's Leukemia & Cancer Research Foundation","Cure Brain Cancer Foundation","Neurosurgical Research Foundation Chris Adams","Neurosurgical Research Foundation"],"pagination":["2943-2958"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12908485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(11)"],"pubmed_abstract":["Background
Ion channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG patient tumors, to identify ion channel-targeting drugs that would inhibit tumor-promoting processes.Methods
We used weighted gene co-expression network analysis (WGCNA) of RNAseq data to identify ion channel gene hubs in diffuse midline glioma (DMG) and glioblastoma. Using scRNA-seq, spatial transcriptomics, and immunohistochemistry, we characterized the expression of identified hubs within patient tumors, validating their role by testing the efficacy of ion channel inhibitors alone or in combination with radiation and temozolomide on the growth and invasion"],"journal":["Neuro-oncology"],"pubmed_title":["Novel GABAAR antagonists target networked gene hubs at the leading edge in high-grade gliomas."],"pmcid":["PMC12908485"],"funding_grant_id":["2023/GNT2030541","2021/GNT2013180"],"pubmed_authors":["Valvi S","Jones ME","Palethorpe HM","Francis A","Shard C","Jones AC","Mahajan I","Patil A","Johns TG","Gomez GA","Yeow Y","Kuznetsova I","Fouladzadeh A","Ying Ng Z","Barker M","Dewdney B","Poonnoose SI","Bosco A","Forrest ARR","Fletcher EV","Ormsby RJ","Boyle Y","Rezaeiravesh S"],"additional_accession":[]},"is_claimable":false,"name":"Novel GABAAR antagonists target networked gene hubs at the leading edge in high-grade gliomas.","description":"Background
Ion channel activity underlying biological processes that drive high-grade gliomas (HGG) is largely unknown. We aimed to determine the networking of ion channel genes and validate their expression within HGG patient tumors, to identify ion channel-targeting drugs that would inhibit tumor-promoting processes.Methods
We used weighted gene co-expression network analysis (WGCNA) of RNAseq data to identify ion channel gene hubs in diffuse midline glioma (DMG) and glioblastoma. Using scRNA-seq, spatial transcriptomics, and immunohistochemistry, we characterized the expression of identified hubs within patient tumors, validating their role by testing the efficacy of ion channel inhibitors alone or in combination with radiation and temozolomide on the growth and invasion","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-07-16T05:07:42.628Z","creation":"2026-07-10T03:08:50.46Z"},"accession":"S-EPMC12908485","cross_references":{"pubmed":["40497637"],"doi":["10.1093/neuonc/noaf143"]}}