{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ma H"],"funding":["Ningbo Major Research and Development Plan Project"],"pagination":["e47337"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12908769"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["105(7)"],"pubmed_abstract":["Chronic obstructive pulmonary disease (COPD) and acute kidney injury (AKI) are significant public health burdens, and emerging observational studies have suggested a potential link between them. However, causality remains unclear. This study aimed to investigate the causal relationship between COPD and AKI using two-sample Mendelian randomization (MR) analyses. We utilized 11 independent single-nucleotide polymorphisms associated with COPD to perform two-sample MR analyses on 2 AKI datasets (GCST90018790 and ACUTERENFAIL). Inverse variance weighted (IVW), weighted median, MR-Egger, and weighted mode methods were employed to estimate causal effects. Sensitivity analyses included MR-Egger intercept tests for directional pleiotropy and Cochran Q tests for heterogeneity. A reverse MR analysis "],"journal":["Medicine"],"pubmed_title":["Exploring the causal relationship between COPD and AKI: A bidirectional Mendelian randomization approach."],"pmcid":["PMC12908769"],"funding_grant_id":["2023Z177"],"pubmed_authors":["Luo Q","Ma H","Zhou F"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the causal relationship between COPD and AKI: A bidirectional Mendelian randomization approach.","description":"Chronic obstructive pulmonary disease (COPD) and acute kidney injury (AKI) are significant public health burdens, and emerging observational studies have suggested a potential link between them. However, causality remains unclear. This study aimed to investigate the causal relationship between COPD and AKI using two-sample Mendelian randomization (MR) analyses. We utilized 11 independent single-nucleotide polymorphisms associated with COPD to perform two-sample MR analyses on 2 AKI datasets (GCST90018790 and ACUTERENFAIL). Inverse variance weighted (IVW), weighted median, MR-Egger, and weighted mode methods were employed to estimate causal effects. Sensitivity analyses included MR-Egger intercept tests for directional pleiotropy and Cochran Q tests for heterogeneity. A reverse MR analysis ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-07-16T05:04:57.225Z","creation":"2026-07-09T10:37:43.844Z"},"accession":"S-EPMC12908769","cross_references":{"pubmed":["41686622"],"doi":["10.1097/MD.0000000000047337"]}}