biostudies-literatureMa HNingbo Major Research and Development Plan Projecte47337https://www.ebi.ac.uk/biostudies/studies/S-EPMC12908769biostudies-literatureUnknown105(7)Chronic obstructive pulmonary disease (COPD) and acute kidney injury (AKI) are significant public health burdens, and emerging observational studies have suggested a potential link between them. However, causality remains unclear. This study aimed to investigate the causal relationship between COPD and AKI using two-sample Mendelian randomization (MR) analyses. We utilized 11 independent single-nucleotide polymorphisms associated with COPD to perform two-sample MR analyses on 2 AKI datasets (GCST90018790 and ACUTERENFAIL). Inverse variance weighted (IVW), weighted median, MR-Egger, and weighted mode methods were employed to estimate causal effects. Sensitivity analyses included MR-Egger intercept tests for directional pleiotropy and Cochran Q tests for heterogeneity. A reverse MR analysis MedicineExploring the causal relationship between COPD and AKI: A bidirectional Mendelian randomization approach.PMC129087692023Z177Luo QMa HZhou FfalseExploring the causal relationship between COPD and AKI: A bidirectional Mendelian randomization approach.Chronic obstructive pulmonary disease (COPD) and acute kidney injury (AKI) are significant public health burdens, and emerging observational studies have suggested a potential link between them. However, causality remains unclear. This study aimed to investigate the causal relationship between COPD and AKI using two-sample Mendelian randomization (MR) analyses. We utilized 11 independent single-nucleotide polymorphisms associated with COPD to perform two-sample MR analyses on 2 AKI datasets (GCST90018790 and ACUTERENFAIL). Inverse variance weighted (IVW), weighted median, MR-Egger, and weighted mode methods were employed to estimate causal effects. Sensitivity analyses included MR-Egger intercept tests for directional pleiotropy and Cochran Q tests for heterogeneity. A reverse MR analysis 2026-01-01T00:00:00Z2026 Feb2026-07-16T05:04:57.225Z2026-07-09T10:37:43.844ZS-EPMC129087694168662210.1097/MD.0000000000047337