biostudies-literatureXu ZJiangsu University Advantage Discipline Construction ProjectProject initiated by researchers from Jiangsu Province Hospital of Chinese MedicineState Administration of Chinese Medicine Projecte47590https://www.ebi.ac.uk/biostudies/studies/S-EPMC12908820biostudies-literatureUnknown105(7)Emerging evidence suggests a profound connection between oral health status and esophageal diseases. Nevertheless, the causal relationship remains controversial. This Mendelian randomization (MR) study was performed to probe into the genetic causality between oral health status and esophageal diseases. Summary statistics from genome-wide association studies were obtained from the FinnGen project and the UK Biobank consortium. The number of instrumental single nucleotide polymorphisms per trait ranged from approximately 8.97 million to 16.38 million. The analyzed datasets included sample sizes of up to 4,63,010 individuals. Univariable MR analyses were conducted to explore the potential bidirectional causality between oral health status and esophageal diseases. Inverse-variance weighted metMedicineOral health status and esophageal diseases: Univariate and multivariate Mendelian randomization analyses.PMC12908820035062005006-05ZDXYS202208-120085-9-1Zou XLiu SXu ZfalseOral health status and esophageal diseases: Univariate and multivariate Mendelian randomization analyses.Emerging evidence suggests a profound connection between oral health status and esophageal diseases. Nevertheless, the causal relationship remains controversial. This Mendelian randomization (MR) study was performed to probe into the genetic causality between oral health status and esophageal diseases. Summary statistics from genome-wide association studies were obtained from the FinnGen project and the UK Biobank consortium. The number of instrumental single nucleotide polymorphisms per trait ranged from approximately 8.97 million to 16.38 million. The analyzed datasets included sample sizes of up to 4,63,010 individuals. Univariable MR analyses were conducted to explore the potential bidirectional causality between oral health status and esophageal diseases. Inverse-variance weighted met2026-01-01T00:00:00Z2026 Feb2026-07-16T00:09:05.287Z2026-07-09T10:26:07.046ZS-EPMC129088204168660010.1097/MD.0000000000047590