biostudies-literatureUnknown15(1)Chang HY<h4>Background</h4>Guideline-directed medical therapy (GDMT) improves outcomes in heart failure with reduced ejection fraction, yet its adoption across Asia remains suboptimal. The American Heart Association launched the GWTG-HF A.S.I.A. (Get With The Guidelines-Heart Failure Adherence to Science, Implementation in Asia) program in 2021. We examined the association between program participation and GDMT implementation in Taiwan.<h4>Methods</h4>We analyzed 1991 patients with heart failure with reduced ejection fraction enrolled in the Taiwan Society of Cardiology HF Registry (2021-2024). Four hospitals participated in the GWTG-HF A.S.I.A. program (n=462) and 23 nonparticipating hospitals served as controls (n=1529). After propensity-score matching, prescription trends of 4-pillar GDMTs wereJournal of the American Heart Associatione047097https://www.ebi.ac.uk/biostudies/studies/S-EPMC12909023biostudies-literatureImplementation of the Get With The Guidelines-Heart Failure Adherence to Science, Implementation in Asia (GWTG-HF A.S.I.A.) Program in Taiwan.PMC12909023Allen LASung SHChang HYLiao CTHeidenreich PAHuang NHsu CYWang TDLi YHChen WJWu YWfalseImplementation of the Get With The Guidelines-Heart Failure Adherence to Science, Implementation in Asia (GWTG-HF A.S.I.A.) Program in Taiwan.<h4>Background</h4>Guideline-directed medical therapy (GDMT) improves outcomes in heart failure with reduced ejection fraction, yet its adoption across Asia remains suboptimal. The American Heart Association launched the GWTG-HF A.S.I.A. (Get With The Guidelines-Heart Failure Adherence to Science, Implementation in Asia) program in 2021. We examined the association between program participation and GDMT implementation in Taiwan.<h4>Methods</h4>We analyzed 1991 patients with heart failure with reduced ejection fraction enrolled in the Taiwan Society of Cardiology HF Registry (2021-2024). Four hospitals participated in the GWTG-HF A.S.I.A. program (n=462) and 23 nonparticipating hospitals served as controls (n=1529). After propensity-score matching, prescription trends of 4-pillar GDMTs were2026-01-01T00:00:00Z2026 Jan2026-07-15T16:26:43.185Z2026-07-07T03:07:26.142ZS-EPMC129090234141375910.1161/JAHA.125.047097