{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Maskatia SA"],"pubmed_abstract":["<h4>Background</h4>Current models to predict outcomes in advanced twin-twin transfusion syndrome are limited. We hypothesized that twin and cotwin echocardiographic factors would improve model performance for donor and recipient demise following laser photocoagulation therapy.<h4>Methods</h4>We performed a multicenter retrospective cohort study of stage 3 to 4 twin-twin transfusion syndrome referred for laser photocoagulation therapy. Fetal echocardiograms were analyzed at a core laboratory. We used multivariable logistic regression models to select variables used for generalized linear mixed-effects modeling. Separate models were developed for donor and recipient demise, using both twin and cotwin variables. Models were assessed by area under the receiver operating characteristic curves.<"],"journal":["Journal of the American Heart Association"],"pagination":["e045070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12909029"],"repository":["biostudies-literature"],"pubmed_title":["Twin and Cotwin Predictors of Fetal Demise After Laser Photocoagulation Therapy in Advanced Stage Twin-Twin Transfusion Syndrome: A Fetal Heart Society Research Collaborative Study."],"pmcid":["PMC12909029"],"pubmed_authors":["Divanovic A","Ghimire L","Howley L","Freud L","Chou FS","Maskatia SA","Annavajjhala V","Yilmaz B","Moon-Grady AJ"],"additional_accession":[]},"is_claimable":false,"name":"Twin and Cotwin Predictors of Fetal Demise After Laser Photocoagulation Therapy in Advanced Stage Twin-Twin Transfusion Syndrome: A Fetal Heart Society Research Collaborative Study.","description":"<h4>Background</h4>Current models to predict outcomes in advanced twin-twin transfusion syndrome are limited. We hypothesized that twin and cotwin echocardiographic factors would improve model performance for donor and recipient demise following laser photocoagulation therapy.<h4>Methods</h4>We performed a multicenter retrospective cohort study of stage 3 to 4 twin-twin transfusion syndrome referred for laser photocoagulation therapy. Fetal echocardiograms were analyzed at a core laboratory. We used multivariable logistic regression models to select variables used for generalized linear mixed-effects modeling. Separate models were developed for donor and recipient demise, using both twin and cotwin variables. Models were assessed by area under the receiver operating characteristic curves.<","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T21:29:11.984Z","creation":"2026-07-09T10:14:40.345Z"},"accession":"S-EPMC12909029","cross_references":{"pubmed":["41432013"],"doi":["10.1161/JAHA.125.045070"]}}