biostudies-literatureUnknown15(1)Maskatia SA<h4>Background</h4>Current models to predict outcomes in advanced twin-twin transfusion syndrome are limited. We hypothesized that twin and cotwin echocardiographic factors would improve model performance for donor and recipient demise following laser photocoagulation therapy.<h4>Methods</h4>We performed a multicenter retrospective cohort study of stage 3 to 4 twin-twin transfusion syndrome referred for laser photocoagulation therapy. Fetal echocardiograms were analyzed at a core laboratory. We used multivariable logistic regression models to select variables used for generalized linear mixed-effects modeling. Separate models were developed for donor and recipient demise, using both twin and cotwin variables. Models were assessed by area under the receiver operating characteristic curves.<Journal of the American Heart Associatione045070https://www.ebi.ac.uk/biostudies/studies/S-EPMC12909029biostudies-literatureTwin and Cotwin Predictors of Fetal Demise After Laser Photocoagulation Therapy in Advanced Stage Twin-Twin Transfusion Syndrome: A Fetal Heart Society Research Collaborative Study.PMC12909029Divanovic AGhimire LHowley LFreud LChou FSMaskatia SAAnnavajjhala VYilmaz BMoon-Grady AJfalseTwin and Cotwin Predictors of Fetal Demise After Laser Photocoagulation Therapy in Advanced Stage Twin-Twin Transfusion Syndrome: A Fetal Heart Society Research Collaborative Study.<h4>Background</h4>Current models to predict outcomes in advanced twin-twin transfusion syndrome are limited. We hypothesized that twin and cotwin echocardiographic factors would improve model performance for donor and recipient demise following laser photocoagulation therapy.<h4>Methods</h4>We performed a multicenter retrospective cohort study of stage 3 to 4 twin-twin transfusion syndrome referred for laser photocoagulation therapy. Fetal echocardiograms were analyzed at a core laboratory. We used multivariable logistic regression models to select variables used for generalized linear mixed-effects modeling. Separate models were developed for donor and recipient demise, using both twin and cotwin variables. Models were assessed by area under the receiver operating characteristic curves.<2026-01-01T00:00:00Z2026 Jan2026-07-15T21:29:11.984Z2026-07-09T10:14:40.345ZS-EPMC129090294143201310.1161/JAHA.125.045070