{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(1)"],"submitter":["Daniels AJ"],"pubmed_abstract":["The Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating brain aging and autosomal dominant Alzheimer's disease (ADAD), a rare monogenic form of Alzheimer's disease (AD). Established in 2008 with support from the National Institute on Aging (NIA), DIAN Obs is designed to collect comprehensive and uniform data with the aim to characterize brain biology and clinical trajectory of individuals at risk for ADAD. Mutations in the amyloid protein precursor (<i>APP</i>), presenilin 1 (<i>PSEN1</i>), or presenilin 2 (<i>PSEN2</i>) genes cause ADAD with virtually full penetrance and a predictable age at symptomatic onset. Participants, both mutation carriers and non-carriers from affected families, undergo longitudinal clinical an"],"journal":["NPJ dementia"],"pagination":["13"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12909123"],"repository":["biostudies-literature"],"pubmed_title":["15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN."],"pmcid":["PMC12909123"],"pubmed_authors":["Fox NC","Chhatwal JP","Brooks WS","Stauber J","Nicklaus J","Laske C","Masters C","Herries E","Dominantly Inherited Alzheimer Network","Allegri RF","Daniels AJ","Xu J","Ramirez L","Cruchaga C","Gordon BA","Martins R","Levey A","Xu X","Johnson ECB","Cash DM","Marsh J","Hornbeck R","Salloway S","McKay N","Courtney L","Gremminger E","Koudelis D","Supnet-Bell C","Massoumzadeh P","Jerome G","Ryan NS","Keefe S","Perrin RJ","Simmons A","Kuder-Buletta E","Rosa-Neto P","Llibre-Guerra JJ","Ikeuchi T","Holtzman DM","Karch C","Aguillon D","Ikonomovic S","Schofield PR","Barthelemy N","McCullough A","Voglein J","Hofmann A","Jucker M","Rizzo J","Noble JM","Farlow MR","Day GS","Fagan AM","Nadkarni NK","Bateman RJ","Wang G","Roedenbeck Y","Bechara JA","Graff-Radford NR","Niimi Y","Berman SB","Baker B","Graber-Sultan S","Seyfried NT","Obermueller U","Ringman J","Wang Q","Lee JH","Chen C","Li Y","Chen A","Picarello DM","Takada L","Flores S","Xiong C","Minton M","Renton AE","Lu R","Franklin E","Sullivan J","Chrem P","Stout S","Scott J","Kasuga K","Sosa AL","Mori H","Milena Y","Buckles V","Pulizos C","Ibanez L","Jackson K","Vazquez S","Hassenstab J","Joseph-Mathurin N","Smith H","Roh JH","McDade E","Morris JC","Sabaredzovic E","Levin J","Aschenbrenner AJ","Surace E","Goate A","Sanchez-Valle R","Huey E","Jarman S","Benzinger TLS","Lopera F"],"additional_accession":[]},"is_claimable":false,"name":"15 years of longitudinal genetic, clinical, cognitive, imaging, and biochemical measures in DIAN.","description":"The Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs) is a longitudinal, global cohort study investigating brain aging and autosomal dominant Alzheimer's disease (ADAD), a rare monogenic form of Alzheimer's disease (AD). Established in 2008 with support from the National Institute on Aging (NIA), DIAN Obs is designed to collect comprehensive and uniform data with the aim to characterize brain biology and clinical trajectory of individuals at risk for ADAD. Mutations in the amyloid protein precursor (<i>APP</i>), presenilin 1 (<i>PSEN1</i>), or presenilin 2 (<i>PSEN2</i>) genes cause ADAD with virtually full penetrance and a predictable age at symptomatic onset. Participants, both mutation carriers and non-carriers from affected families, undergo longitudinal clinical an","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026","modification":"2026-07-16T18:07:04.725Z","creation":"2026-07-09T11:10:48.666Z"},"accession":"S-EPMC12909123","cross_references":{"pubmed":["41709913"],"doi":["10.1038/s44400-025-00047-7"]}}