biostudies-literatureGarcia-Arevalo FSecretaría de Ciencia, Humanidades, Tecnología e Innovación17534259261422539https://www.ebi.ac.uk/biostudies/studies/S-EPMC12909751biostudies-literatureUnknown32BackgroundPeriodontitis is one of the most common inflammatory diseases in humans, mostly caused by bacterial infection and with diverse populations of immune cells involved. Myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells derived from hematopoietic precursor cells, have exhibited immunomodulatory functions by production of different molecules such as inducible NO synthase (iNOS) and it is thought to be involved in periodontitis. However, reports of characterization of cells with MDSC phenotypes in gingival tissues are very scarce. This study aimed to characterize gingival cells with MDSC phenotypes in healthy gingiva and periodontitis tissues.Methods and ResultsHuman healthy gingival tissues and those with periodontitis were included to analyze ceInnate immunityPeriodontitis promotes gingival accumulation of cells with MDSC phenotype.PMC12909751CF-2023-I-1400Gonzalez-Ramirez JSerafin-Higuera NFuchen-Ramos DMIsiordia-Espinoza MGarcia-Arevalo FLeija-Montoya GfalsePeriodontitis promotes gingival accumulation of cells with MDSC phenotype.BackgroundPeriodontitis is one of the most common inflammatory diseases in humans, mostly caused by bacterial infection and with diverse populations of immune cells involved. Myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells derived from hematopoietic precursor cells, have exhibited immunomodulatory functions by production of different molecules such as inducible NO synthase (iNOS) and it is thought to be involved in periodontitis. However, reports of characterization of cells with MDSC phenotypes in gingival tissues are very scarce. This study aimed to characterize gingival cells with MDSC phenotypes in healthy gingiva and periodontitis tissues.Methods and ResultsHuman healthy gingival tissues and those with periodontitis were included to analyze ce2026-01-01T00:00:00Z2026 Jan-Dec2026-07-16T00:47:14.693Z2026-07-09T10:26:27.275ZS-EPMC129097514169332510.1177/17534259261422539