{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Desai S"],"pubmed_abstract":["<h4>Background</h4>Radical cystectomy (RC) with urinary diversion remains the standard of care for muscle invasive bladder cancer. While metabolic acidosis (MA) after RC is common, the relationship between MA, post-operative complications, and the impact of bicarbonate supplementation remains unclear.<h4>Objective</h4>To review the role of bicarbonate therapy for MA following RC.<h4>Methods</h4>We performed a comprehensive systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines analyzing MA after RC. We included randomized controlled trials and cohort studies that reported metabolic acidosis complications and studies that utilized bicarbonate therapy peri-operatively. Our primary outcome was metabolic acidosis or role of metabol"],"journal":["Bladder cancer (Amsterdam, Netherlands)"],"pagination":["23523735261424587"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12909775"],"repository":["biostudies-literature"],"pubmed_title":["Systematic review: The role of bicarbonate therapy after urinary diversion."],"pmcid":["PMC12909775"],"pubmed_authors":["Tan HJ","Smith A","Gessner KH","Frisbie J","Moreton E","Nielsen M","Desai S","Bjurlin M"],"additional_accession":[]},"is_claimable":false,"name":"Systematic review: The role of bicarbonate therapy after urinary diversion.","description":"<h4>Background</h4>Radical cystectomy (RC) with urinary diversion remains the standard of care for muscle invasive bladder cancer. While metabolic acidosis (MA) after RC is common, the relationship between MA, post-operative complications, and the impact of bicarbonate supplementation remains unclear.<h4>Objective</h4>To review the role of bicarbonate therapy for MA following RC.<h4>Methods</h4>We performed a comprehensive systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines analyzing MA after RC. We included randomized controlled trials and cohort studies that reported metabolic acidosis complications and studies that utilized bicarbonate therapy peri-operatively. Our primary outcome was metabolic acidosis or role of metabol","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan-Mar","modification":"2026-07-16T05:17:43.674Z","creation":"2026-07-09T13:10:21.561Z"},"accession":"S-EPMC12909775","cross_references":{"pubmed":["41710209"],"doi":["10.1177/23523735261424587"]}}