{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou Y"],"funding":["National Key R&D Program of China","National Key R&D Program of China","Agricultural Key-scientific and Core-technological Project of Shaanxi Province","Shaanxi Science and Technology Innovation Team Project","Xianyang City Major Science and Technology Innovation Project"],"pagination":["6411"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12909831"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Polyvinyl alcohol (PVA) is a widely used industrial polymer, and its persistence in the environment poses significant challenges, making the study of its biodegradation both a major production concern and an important scientific issue. This study aimed to elucidate the enzymatic mechanisms of PVA biodegradation by identifying and characterizing a novel oxidized polyvinyl alcohol hydrolase (OPH) from Stenotrophomonas rhizophila QL-P4, and to investigate its evolutionary divergence across microbial species. Through genomic analysis, we identified a gene, BAY15_0160 (996 bp), encoding a putative OPH. Its essential role in PVA degradation was confirmed via gene deletion, overexpression, and functional complementation assays. Site-directed mutagenesis demonstrated that the signal peptide and ac"],"journal":["Scientific reports"],"pubmed_title":["Mechanism and evolutionary divergence of a novel oxidized polyvinyl alcohol hydrolase in Stenotrophomonas rhizophila QL-P4."],"pmcid":["PMC12909831"],"funding_grant_id":["L2023-ZDKJ-CYJQ-NY-002","2024YFD1700500","2025RS-CXTD-032","2025NYGG011"],"pubmed_authors":["Yao Y","Feng J","Jia C","Huang K","Huang L","Zhou Y","Chen S","Bold N","Wei Y","Qiu L"],"additional_accession":[]},"is_claimable":false,"name":"Mechanism and evolutionary divergence of a novel oxidized polyvinyl alcohol hydrolase in Stenotrophomonas rhizophila QL-P4.","description":"Polyvinyl alcohol (PVA) is a widely used industrial polymer, and its persistence in the environment poses significant challenges, making the study of its biodegradation both a major production concern and an important scientific issue. This study aimed to elucidate the enzymatic mechanisms of PVA biodegradation by identifying and characterizing a novel oxidized polyvinyl alcohol hydrolase (OPH) from Stenotrophomonas rhizophila QL-P4, and to investigate its evolutionary divergence across microbial species. Through genomic analysis, we identified a gene, BAY15_0160 (996 bp), encoding a putative OPH. Its essential role in PVA degradation was confirmed via gene deletion, overexpression, and functional complementation assays. Site-directed mutagenesis demonstrated that the signal peptide and ac","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-16T05:15:31.842Z","creation":"2026-07-09T13:10:01.108Z"},"accession":"S-EPMC12909831","cross_references":{"pubmed":["41593303"],"doi":["10.1038/s41598-026-37715-4"]}}