biostudies-literatureGupta DKU.S. Department of Defense6553https://www.ebi.ac.uk/biostudies/studies/S-EPMC12909838biostudies-literatureUnknown16(1)The Movement Disorders Society clinical diagnostic criteria for Parkinson's disease (MDS-PD) allow highly sensitive and specific diagnosis of Parkinson's disease. However, their adoption has been limited due to lack of a clinical decision support (CDS) tool to support clinicians and researchers in systematically and accurately applying the MDS-PD criteria. We have developed and performed preliminary validation of a CDS platform for PD (CDS-PD) as a modular and extensible informatics platform with comprehensive functionalities for recording relevant patient information. We have performed real-time application of diagnostic algorithm of the MDS-PD criteria. The CDS-PD platform shows high concordance with application of the MDS-PD criteria by experienced movement disorders neurologists for esScientific reportsCDS-PD: a novel clinical decision support platform for Parkinson's disease.PMC12909838W81XWH2110859Golnari PGupta DKSahoo SSPrantzalos KBoyd JTTatsuoka CZurlo IBulusu MClarke DZweber CHiller ALIyer VLobb BMfalseCDS-PD: a novel clinical decision support platform for Parkinson's disease.The Movement Disorders Society clinical diagnostic criteria for Parkinson's disease (MDS-PD) allow highly sensitive and specific diagnosis of Parkinson's disease. However, their adoption has been limited due to lack of a clinical decision support (CDS) tool to support clinicians and researchers in systematically and accurately applying the MDS-PD criteria. We have developed and performed preliminary validation of a CDS platform for PD (CDS-PD) as a modular and extensible informatics platform with comprehensive functionalities for recording relevant patient information. We have performed real-time application of diagnostic algorithm of the MDS-PD criteria. The CDS-PD platform shows high concordance with application of the MDS-PD criteria by experienced movement disorders neurologists for es2026-01-01T00:00:00Z2026 Jan2026-07-16T00:37:48.821Z2026-07-09T10:26:22.052ZS-EPMC129098384159318410.1038/s41598-026-37316-1